JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
January 2018
U-M17

SIGNALMENT (JPC #2182655):  Tissue from a 35-day-old Finnish-Landrace cross lamb

HISTORY:  Euthanized following a two-day episode of anorexia and depression

MICROSCOPIC DESCRIPTION:  Kidney:  Diffusely and globally, glomerular tufts are hypercellular and lobulated with increased mesangial cells and infiltration by variable numbers of neutrophils; glomerular capillary basement membranes are variably thickened by eosinophilic, homogenous material.  Multifocally, glomeruli further exhibit one or more of the following changes: uriniferous spaces occasionally contain pale, eosinophilic, homogenous material (protein) and/or eosinophilic beaded fibrillar fibrin with cellular infiltration (crescent formation); and/or there is occasional hypertrophy and hyperplasia of the parietal and visceral layers of Bowman's capsule.   Multifocally, predominantly around glomeruli, the interstitium is expanded by small aggregates of many lymphocytes, fewer plasma cells, rare neutrophils, eosinophils, and variable amounts of fibrosis.  Rarely, tubules are mildly ectatic and contain eosinophilic, homogenous material (proteinaceous fluid), hemorrhage, or sloughed cells and cellular and karyorrhectic debris (cellular casts).  Multifocally, tubular epithelial cells exhibit one or more of the following changes: attenuation and flattening; hypereosinophilic epithelial cytoplasm with pyknotic nuclei (necrosis); microvacuolated epithelial cytoplasm with rare hyaline droplets (degeneration); slightly basophilic cytoplasm with vesiculate nuclei and occasional mitoses (regeneration).  Multifocally, the perivascular interstitium is mildly expanded by increased clear space (edema).

MORPHOLOGIC DIAGNOSIS:  Kidney:  Glomerulonephritis, membranoproliferative (mesangiocapillary), neutrophilic, global, diffuse, moderate, with crescent formation and lymphoplasmacytic interstitial nephritis, Finnish-Landrace cross, ovine.

ETIOLOGIC DIAGNOSIS:  Hereditary glomerulonephritis

GENERAL DISCUSSION: 

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ULTRASTRUCTURE FINDINGS: 

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS: 

COMPARATIVE PATHOLOGY: 

REFERENCES: 

  1. Angus KW. Nephropathy in young lambs. Vet Rec. 1990;126(21):525-528.
  2. Angus KW, Gardiner AC. Mesangiocapillary glomerulonephritis in Dorset-Finnish landrace cross lambs. Vet Rec. 1979;105(20):471.
  3. Angus KW, Gardiner AC, Mitchell B, Thomson D. Mesangiocapillary glomerulonephritis in lambs: the ultrastructure and immunopathology of diffuse glomerulonephritis in newly born Finnish landrace lambs. J Pathol. 1980;131(1):65-74.
  4. Breshears MA, Confer AW. Urinary system. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:644-653.
  5. Cianciolo RE, Mohr FC. Urinary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol. 2. 6th ed. Philadelphia, PA: Elsevier; 2016:401-417.
  6. Cianciolo RE, Mohr FC, Aresu L, et al. World Small Animal Veterinary Association renal pathology initiative: Classification of glomerular diseases in dogs. Vet Pathol.  2016 Jan;53(1):113-135.
  7. Constable PD, Hinchcliff KW, Done SH, Gruenberg W. Diseases of the Kidney. In: Veterinary Medicine, A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs, and Goats. 11th ed. New York, NY: Elsevier; 2017: 1110-1111.
  8. Gonzales-Viera O, Ruoppolo V, Marigo J, et al. Renal lesions in cetaceans from Brazil.  J Comp Pathol.  2015 May;152(4):345-354.
  9. Tizard IR. Veterinary Immunology: An Introduction. 8th ed. Philadelphia, PA: Elsevier; 2009:361-364.
  10. Trang NT, Hirai T, Nabeta R, et al. Membranoproliferative glomerulonephritis in a calf with nephrotic syndrome.  J Comp Pathol.  2014 Aug-Oct;151(2-3):162-165.

 


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