JPC SYSTEMIC PATHOLOGY
HEMOLYMPHATIC SYSTEM
April 2018
H-V07

Signalment:  Young chicken

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Bursa of Fabricius:  There is atrophy of bursal follicles and diffusely within the cortex and the medulla, there is marked lymphoid depletion.  Undifferentiated epithelial cells within the medulla are prominent. Multifocally, follicular medullas often contain eosinophilic cellular and karyorrhectic debris (lymphocytolysis) admixed with macrophages that occasionally contain phagocytized cellular debris. Multifocally, lymphoid follicles contain dilated and congested vessels, mild hemorrhage and low to moderate numbers of infiltrating heterophils. Diffusely the interfollicular connective tissue, and to lesser degree follicular cortical areas are markedly expanded by clear space and lymphatics are multifocally ectatic (edema).  Scattered heterophils transmigrate the surface epithelium, which is multifocally mildly attenuated.

MORPHOLOGIC DIAGNOSIS:  Bursa of Fabricius:  Lymphoid depletion, acute, diffuse, moderate, with lymphocytolysis and mild heterophilic bursitis, breed unspecified, chicken, avian.

ETIOLOGIC DIAGNOSIS:  Avian birnaviral bursitis

CAUSE:  Infectious bursal disease virus

CONDITION:  Infectious bursal disease (IBD)

SYNONYMS:  Gumboro disease, avian infectious bursitis

GENERAL DISCUSSION: 

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY: 

Other viruses in family Birnaviridae:

References:    

  1. Abdul-Aziz T, Barnes HJ, Gross Pathology of Avian Diseases. Philadelphia, PA: American Association of Avian Pathologists; 2018:83-86.
  2. Abdul-Aziz T, Fletcher OJ, Barnes HJ. Avian Histopathology. 4th Philadelphia, PA: American Association of Avian Pathologists; 2016: 20, 37-41.
  3. Brash ML, Charlton BR, Fitz-Coy SH, et al. Avian Disease Manual. 7th ed. Philadelphia, PA: American Association of Avian Pathologists; 2013:55-58.
  4. Dwight IA, Coates PS, Stoute ST, et al. Serologic Surveillance of Wild and Pen-Reared Ring-Necked Pheasants ( Phasianus colchicus) as a Method of Understanding Disease Reservoirs. J Wildl Dis. 2017 Dec 20. doi: 10.7589/2017-08-191. [Epub ahead of print]
  5. Eterradossi N, Saif YM. Infectious bursal disease. In: Diseases of Poultry. 13th ed. Ames, IA: Blackwell Publishing; 2013:219-246.
  6. Guy JS, West MA, Fuller FJ. Physical and genomic characteristics identify chicken proventricular necrosis virus (R11/3 virus) as a novel birnavirus. Avian Dis. 2011;55(1):2-7.
  7. Jackwood DJ, Stoute ST, Crossley BM. Pathogenicity of Genome Reassortant Infectious Bursal Disease Viruses in Chickens and Turkeys. Avian Dis. 2016 Dec;60(4):765-772.
  8. Jordan FTW, Patterson M. Poultry Diseases. 6th ed. Philadelphia, PA: WB Saunders Company Ltd; 2008:359-366.
  9. MacLachlan NJ, Dubovi EJ, eds. Birnaviridae. In: Fenner’s Veterinary Virology. 4th ed. San Diego, CA: Academic Press; 2011:293-297.
  10. Randall CJ, Reece RL. Color Atlas of Avian Histopathology. Alfred Place, London: Mosby-Wolfe; 1996:105-109.
  11. Stoute ST, Jackwood DJ, Sommer-Waqgner SE,et al. Pathogenicity associated with coinfection with very virulent infectious bursal disease and Infectious bursal disease virus strains endemic in the United States. J Vet Diag Invest. 2013; 25(3):352-358.


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