JPC SYSTEMIC PATHOLOGY
Reproductive System
January 2019
R-M06 (NP)

Signalment (JPC #1454646):  Dog

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Testis and epididymis:  Expanding the connective tissue of the epididymis are multiple granulomas, up to 3x6 mm, composed of a central area containing numerous degenerate spermatozoa and inflammatory cells, clear acicular clefts (cholesterol), and abundant eosinophilic cellular and karyorrhectic debris.  This area is rimmed by a zone of lymphocytes, plasma cells, epithelioid macrophages, and rare multinucleated giant cells that is further surrounded by thin band of fibrous connective tissue.  Multifocally within the surrounding connective tissue, there are few lymphocytes, plasma cells, and occasional macrophages, some of which contain granular, golden-brown pigment (hemosiderin).  Within the epididymis there is diffuse aspermia.  Within the testis, seminiferous tubules are degenerate with an undulant basement membrane, vacuolated Sertoli cells, and decreased amounts of mature sperm. Multifocally in the testis low numbers of similar inflammatory cells infiltrate and surround seminiferous tubules and there are rare multinucleated spermatids.

MORPHOLOGIC DIAGNOSIS:

1. Epididymis:  Sperm granuloma, multiple, breed not specified, canine.
2. Testis, seminiferous tubules: Degeneration, diffuse, moderate with hypospermatogenesis and lymphoplasmacytic orchitis, multifocal, mild. 

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Brinsko SP, Blanchard TL, Varner DD. Diseases of the reproductive system, male reproductive disorders. In: Smith BP, ed. Large animal internal medicine. 4th ed. St. Louis, MO: Mosby Elsevier; 2008: 1483.
  2. Chaffee BK, Beck AP, Owsteon MA, Kumar S, et al. Spontaneous reproductive tract lesions in aged captive chimpanzees. Vet Pathol. 2016;53(2):425-435.
  3. Foster RA. Male reproductive system. In: McGavin MD, Zachary JF, eds. Pathologic Basis of Veterinary Disease. 5th ed. St. Louis, MO: Mosby Elsevier; 2012: 1129, 1135, 1140-1141.
  4. Foster RA. Male genital system.  In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. Philadelphia, PA: Saunders Elsevier; 2016: 480-481, 497.
  5. Heuser A, Mecklenburg L, Ockert D, Kohler M, Kemkowski J. Selective inhibition of PDE4 in Wistar rats can lead to dilatation in testis, efferent ducts, and epididymis and subsequent formation of sperm granulomas. Toxicol Pathol. 2013;41(4):615-627.


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