JPC Systemic Pathology
Digestive System
November 2018
D-V12 (NP)

Signalment (JPC #1171326):  A guinea pig

HISTORY:  Incidental finding

HISTOPATHOLOGIC DESCRIPTION:  Salivary gland:  Multifocally within periductal areas the interstitium is expanded by moderate numbers of lymphocytes and fewer plasma cells and macrophages, admixed with small amounts of necrotic cellular and karyorrhectic debris.  Multifocally, rare acinar cells are enlarged up to ten times normal (cytomegaly), with abundant eosinophilic granular cytoplasm and one to two nuclei containing an 8-12 um diameter, deeply eosinophilic, round to oval intranuclear inclusion body which marginates the chromatin (“owl eye cells”).  Multifocally, there is deeply basophilic mineral.

MORPHOLOGIC DIAGNOSIS:  Salivary gland:  Sialoadenitis, lymphoplasmacytic, multifocal, mild, with rare acinar eosinophilic inclusion bodies, breed unspecified, guinea pig (Cavia porcellus), rodent.

ETIOLOGIC DIAGNOSIS:  Herpesviral sialoadenitis

CAUSE:  Guinea pig cytomegalovirus (GPCMV); Caviid herpesvirus 2

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:  None

TYPICAL GROSS FINDINGS:  None

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIAGNOSIS:

DIFFERENTIAL DIAGNOSIS:  (For intranuclear inclusions)

COMPARATIVE PATHOLOGY:

 REFERENCES:

  1. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, IA: John Wiley & Sons, Inc; 2016: 218-219.
  2. Mauldin EA, Peters-Kennedy J. Integumentary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer"s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier; 2016:626-627.
  3. Murphy FA, Gibbs EPJ, Horzinek MC, Studdert MJ. Herpesvirdae. In: Veterinary Virology. 3rd ed. New York, NY: Academic Press; 1999:301-322.
  4. Schlafer DH, Foster RA. Female genital system. In: Maxie MG, ed. Jubb, Kennedy and Palmer"s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier; 2016: 433, 435.
  5. Wachtman L, Mansfield K. Viral disease of nonhuman primates. In: Abee CR, Mansfield K, Tardif S, Morris T. Nonhuman Primates in Biomedical Research: Diseases. 2nd ed. San Diego, CA: Academic Press; 2012: 19-21.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |