JPC SYSTEMIC PATHOLOGY
REPRODUCTIVE SYSTEM
JANUARY 2019
R-B01

Signalment (JPC #1946318):  An aborted Angus bull calf.

HISTORY:  The fetus aborted at approximately 6 months of gestation.  This was the second first-time heifer to have aborted on this previously non-grazed ranch.   The liver was markedly enlarged with rounded margins and had a cobblestone appearance with multiple, pinpoint, white foci scattered throughout; the spleen, thymus, and lymph nodes were markedly enlarged.

HISTOPATHOLOGIC DESCRIPTION:  Thymus:  The thymic medulla is diffusely expanded by high numbers of epithelioid macrophages admixed with fewer lymphocytes, plasma cells, and rare eosinophils.  Macrophages are characterized by abundant amphophilic, granular cytoplasm, and often contain phagocytosed cellular debris or occasionally contain erythrocytes (erythrophagocytosis) or hemosiderin.  The thymic cortex demonstrates marked lymphoid depletion characterized by marked thinning and pallor, frequent karyorrhectic lymphocytes, and high numbers of tingible body macrophages.  There is multifocal mild hemorrhage of the cortex and medulla, and the interlobular connective tissue is edematous and contains low numbers of previously mentioned inflammatory cells.

Heart, myocardium and valve:  The endocardium is mildly expanded by moderate numbers of infiltrating macrophages and few lymphocytes and plasma cells.  Similar inflammatory infiltrates are scattered throughout the myocardium, primarily in perivascular areas, as well as within the epicardium and pericardial adipose tissue.

MORPHOLOGIC DIAGNOSES: 

  1. Thymus: Thymitis, granulomatous, diffuse, marked, with marked lymphoid depletion.
  2. Heart: Pancarditis, granulomatous, diffuse, mild.

ETIOLOGIC DIAGNOSIS:  Deltaproteobacterial thymitis and pancarditis

ETIOLOGY:  A deltaproteobacterium

CONDITION:  Epizootic bovine abortion (EBA), Foothills abortion

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

Bovine abortion:

Fetus, grossly nodular liver:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Blanchard MT, Anderson ML, Hoar BR, et. al. Assessment of a fluorescent antibody test for the detection of antibodies against epizootic bovine abortion.  Jour Vet Diagn Invest.  2014;26(5):622-630.
  2. Brooks RS, Blanchard MT, Clothier KA, Fish S, Fish S, Anderson ML, Stott JL. Characterization of Pajaroellobacter abortibovis, the etiologic agent of epizootic bovine abortion.  Vet Microbiol.  2016;192:73-80.
  3. Foster RA. Female reproductive system and mammae. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2016: 1181.
  4. Schlafer DH, Foster RA. Female genital system. In: Maxie MG, ed. Jubb Kennedy and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:419-420.
  5. Valli VEO, Kiupel M, Bienzle H. The hematopoietic system. In: Maxie MG, ed. Jubb Kennedy and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:148, 149.


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