JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
September 2018
D-M03 (NP)

SIGNALMENT (JPC #1758202):  7-year old German shepherd dog

HISTORY: Incidental finding

MICROSCOPIC DESCRIPTION: Stomach, fundus:  Multifocally, hyperplastic mucosal epithelial cells form additional rugal folds between pre-existing gastric furrows and markedly thicken gastric pits.  Hyperplastic cells pile up to five layers thick and demonstrate mild anisokaryosis.  The subepithelial lamina propria is expanded by multifocal aggregates of lymphoplasmacytic cells that often transmigrate the gastric mucosal epithelium.

MORPHOLOGIC DIAGNOSIS: Stomach, fundus, epithelial mucosa: Hyperplasia, multifocal, chronic, moderate, with lymphoplasmacytic infiltration, German shepherd, canine.

ETIOLOGY:  Unknown

CONDITION: Chronic hypertrophic gastritis

GENERAL: 

PATHOGENESIS:  Unknown

TYPICAL CLINICAL FINDINGS

TYPICAL GROSS FINDINGS:

TYPICAL MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

Parasitic gastritis in many species:

REFERENCES:

  1. Gelberg HB. Alimentary system and the peritoneum, omentum, mesentery, and peritoneal cavity. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:363.
  2. Uzal FA, Plattner BL, Hostetter JM. Alimentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier Ltd; 2016:100-101; 53


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