October 2018

Signalment (JPC #1621137):  A dog


HISTOPATHOGIC descriptionEsophagus:  Focally expanding the tunica muscularis, compressing adjacent skeletal myocytes and overlying submucosal glands, and elevating the overlying submucosa and mucosa is a 12 x 8 mm inflammatory nodule centered on  numerous transverse and longitudinal sections of adult spiurid nematodes surrounded by high numbers of plasma cells, macrophages (often hemosiderin-laden), fewer lymphocytes, and rare neutrophils and eosinophils, which extend into the submucosa, tunica muscularis and serosa.  Nematodes and inflammatory cells are surrounded by numerous reactive fibroblasts and small caliber blood vessels (granulation tissue) progressing to more dense fibrous connective tissue (fibrosis).  Adult nematodes are 1 mm in diameter and have an 8 μm thick, smooth cuticle, coelomyarian-polymyarian musculature, prominent lateral cords, a pseudocoelom containing a moderate amount of eosinophilic material, an intestine lined by uninucleate columnar epithelium with a prominent brush border and male or female reproductive organs.  Multifocally, adjacent myocytes are compressed and shrunken (atrophy) and are often separated/replaced by fibrosis.

Morphologic diagnosisEsophagus:  Esophagitis, nodular, fibrosing, lymphoplasmacytic and histiocytic chronic, marked, with adult nematodes, etiology consistent with Spirocerca lupi, breed unspecified, canine.

Etiologic diagnosisEsophageal spirocercosis

CAUSE:  Spirocerca lupi









Esophageal parasites:

Parasites associated with neoplasia (Mnemonic SOCS-T):


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