JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

September 2017

P-M03 (NP)

 

Signalment (JPC #1820691):  Unknown age and gender owl monkey

HISTORY:  Unknown

HISTOPATHOLOGIC DESCRIPTION:  Lung:  Expanding up to 75% of alveolar septa and peribronchial and perivascular interstitium, are multifocal to coalescing granulomas that compress adjacent alveoli and are composed of a center of large numbers of macrophages containing amphophilic to light brown, granular to specular anisotropic material which is also present extracellularly. Surrounding the core of macrophages are rare multinucleated giant cells (Langhans type), with a rim of lymphocytes, plasma cells, with fewer neutrophils.  In less severely affected areas, alveolar lumina are filled with eosinophilic homogenous proteinaceous material (edema) and scattered macrophages.  There is multifocal minimal type II pneumocyte hyperplasia. 

MORPHOLOGIC DIAGNOSIS:  Lung:  Pneumonia, granulomatous, multifocal to coalescing, severe with intraalveolar and intrahistiocytic anisotropic foreign material, owl monkey, Aotus trivirgatus, primate.

ETIOLOGIC DIAGNOSIS:  Inhalation/aspiration (foreign body) pneumonia

CAUSE:  Kaolin

SYNONYMS:  Bolus alba, white clay, China clay, Fuller’s earth

GENERAL:

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSES:

COMPARATIVE PATHOLOGY:

References:

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  2. Bischoff K. Toxicity of over-the-counter drugs. In: Gupta RC ed. Veterinary Toxicology: Basic and Clinical Principles. New York, NY: Academic Press; 2007:388.
  3. Bowden DH, Adamson YR. Fibroblast interactions with alveolar and interstitial macrophages. Models: silicosis and abestosis in the mouse. In: Jones TC, Dungworth DL, Mohr U, eds. Monographs on Pathology of Laboratory Animals: Respiratory System. 2nd ed. New York, NY: Springer-Verlag;1996: 265-269.
  4. Caswell JL, Williams KJ. Respiratory system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol. 2. 6th ed. St. Louis, MO: Elsvier; 2016:508-509, 516.
  5. Haschek WM, Rousseaux CG. Handbook of Toxicologic Pathology. San Diego, CA: Academic Press; 1991:805-809.
  6. Jones TC, Hunt RD, and King NW. Veterinary Pathology. 6th ed. Baltimore, MD: Williams & Wilkins; 1997:65.
  7. Lopez A, Martinson SA. Respiratory system, mediastinum, and pleurae. In: Zachary JF. ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:536-537, 548-549.
  8. Klaassen CD. Casarett & Doull’s Toxicology, The Basic Science of Poisons. 6th ed. New York, NY: McGraw Hill; 2001:526-529.
  9. Naota M, Shiotsu S, Shimada A, Kohara Y, Morita T, Inoue K, Takano H. Pathological study of chronic pulmonary toxicity induced by intratracheally instilled Asian sand dust (kosa). Toxic Pathol. 2013;41:48-62.


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