JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

October 2017

P-V20

 

Signalment (JPC #1850533):  A lamb

HISTORY:  Fever (105o F) and mild dyspnea

HISTOPATHOLOGIC DESCRIPTION:  Lung:  Approximately 70% of the section is affected.  There are multifocal to coalescing areas where bronchi and bronchioles (including terminal bronchioles) contain the following changes: marked epithelial hyperplasia with cells piling up to 10 layers thick and occasional mitoses; marked epithelial hypertrophy with cells enlarged 2-8 times normal containing abundant eosinophilic granular cytoplasm and a large, up to 20 um, vesiculate nucleus with a prominent nucleolus (karyomegaly); occasional intraepithelial 10 um basophilic smudgy intranuclear viral inclusion bodies; neutrophils occasionally expanding the submucosa and transmigrating the epithelium; epithelial single cell necrosis; variable amounts of an exudate composed of many viable and degenerate neutrophils, necrotic cellular debris, sloughed epithelial cells,  fewer macrophages and small amounts of fibrin are present within the lumen.  Multifocally adjacent alveoli are filled with many viable and degenerative neutrophils, fewer macrophages and small amounts of fibrin. Alveolar septa are mild to moderately expanded by eosinophilic beaded to fibrillar material (fibrin), few neutrophils, and increased numbers of macrophages and lymphocytes and are occasionally closely approximated (atelectasis).  There is mild to moderate perivascular edema.

MORPHOLOGIC DIAGNOSIS:  Lung:  Bronchopneumonia, subacute, multifocal, severe, with epithelial hyperplasia, necrosis and epithelial basophilic intranuclear viral inclusion bodies, breed unspecified, ovine.

ETIOLOGY:  Ovine Adenovirus

ETIOLOGIC DIAGNOSIS:  Adenoviral pneumonia

GENERAL DISCUSSION: 

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ADDITIONAL DIAGNOSTIC TESTS: 

ULTRASTRUCTURAL FINDINGS:

DIFFERENTIAL DIAGNOSIS: 

Histologic rule-outs:

Gross rule-outs: Viral pneumonias of sheep

COMPARATIVE PATHOLOGY: 

Four genera:

REFERENCES:

  1. Caswell JL, Williams KJ. Respiratory system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. New York, NY:Elsevier Limited; 2016:542,557,569,577.
  2. Fitzgerald SD, Hess M, Smyth JA, Pierson FW, Reed WM, Jack SW. Adenovirus infections. In: Swayne DE, ed. Diseases of Poultry. 13th ed. Ames, IA: John Wiley & Sons, Inc; 2013: 289-331.
  3. Lopez A, Martinson SA. Respiratory system, mediastinum and pleurae. In: Zachary JF ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:489,546.
  4. MacLachlan NJ, Dubovi EJ. Adenoviridae. In: MacLachlan NJ, Dubovi EJ, eds. Fenner’s Veterinary Virology. 5th ed. San Diego, CA: Elsevier/Academic Press; 2017:217-227.
  5. Ojkic D, Brash ML, Jackwood MW, Shivaprasad HL. Viral diseases.  In: Bouliannw M, ed. Avian Disease Manual. 7th ed. Jacksonville, FL:American Association of Avian Pathologists; 2013:10-17.
  6. Uzal FA, Plattner BL, Hostetter JM. Alimentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. New York, NY:Elsevier Limited; 2016:144-146.

 


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