JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

SEPTEMBER 2017

P-P03

 

Signalment (JPC #2131712): Three‑week‑old broiler cockerel.

HISTORY: Unknown

HISTOPATHOLOGIC DESCRIPTION: Lung: Focally affecting over 60% of the section, parabronchial and air vesicle lumina are variably occluded by numerous lymphocytes and histiocytes, abundant necrotic debris, few viable and degenerate heterophils, hemorrhage, and sloughed epithelial cells. Multifocally, the parabronchial and air vesicle respiratory epithelium is either hyperplastic or attenuated. The affected interstitium is expanded by numerous macrophages, lymphocytes and plasma cells that also obscures air capillary profiles. The lamina propria of the mesobronchus, and to a lesser extent, an adjacent secondary bronchus, are multifocally expanded by increased numbers of lymphocytes and plasma cells that form lymphoid aggregates (hyperplastic bronchial-associated lymphoid tissue). The bronchial respiratory epithelium is hyperplastic, piling up to 3 layers thick, with numerous mitotic figures (regeneration) and occasional loss of cilia. Numerous basophilic, round 2‑5um cryptosporidia either line the ciliated surface of the bronchial epithelium or are within parabronchial lumina

MORPHOLOGIC DIAGNOSES: Lung: Bronchopneumonia, proliferative, subacute, lymphohistiocytic, focally extensive, moderate, with numerous apical protozoa, etiology consistent with Cryptosporidium spp., chicken, avian

ETIOLOGIC DIAGNOSES: Cryptosporidial bronchopneumonia

CAUSE: Cryptosporidium baileyi

GENERAL DISCUSSION:

PATHOGENESIS:

LIFE CYCLE:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

Respiratory: Concurrent infection with bacterial, viral, or fungal organisms is common:

Bursitis: Bursal cryptosporidiosis is commonly seen in chickens with Infectious Bursal Disease (Birnavirus) or chicken anemia virus (Circovirus).

COMPARATIVE PATHOLOGY:

Mammals:

Birds:    

Reptiles:

Fish:

References:

  1. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents & Rabbits, 4th ed. Ames, IA: Blackwell Publishing Ltd; 2016:82,108,152,189,204-205,235-236,297.
  2. Bowman DD. In: Bowman DD, ed. Georgis’ Parasitology for Veterinarians. 10th ed. St. Louis, MO: Saunders Elsevier; 2013:96-98.
  3. Bougiouklis PA, Weissenböck H, Wells A, Miller WA, Palmieri C, Shivaprasad HL. Otitis media associated with Cryptosporidium baileyi in a Saker falcon (Falco cherrug). J Comp Pathol. 2013 May;148(4):419-423.
  4. Boulianne M. Avian Disease Manual. 7th ed., Atlanta, GA:American Association of Avian Pathologists; 2013:107,170-171,176,241,287.
  5. Cheville NF. Ultrasructural Pathology, The Comparative Cellular Basis of Disease. 2nd ed., Ames, IA:Wiley-Blackwell; 2009:555-9.
  6. Gardiner CH, Fayer R, Dubey JP. An Atlas of Protozoan Parasites in Animal Tissues. 2nd ed., Washington, DC:Armed Forces Institute of Pathology, American Registry of Pathology; 1998:37.
  7. Gelburg HB. Alimentary system and the peritoneum, omentum, mesentery, and peritoneal cavity. In: Zachary JF. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Mosby Elsevier; 2017:236-237,382-383.
  8. Masuno K, Yanai T, Hirata A, Yonemaru K, Sakai H, Satoh M, Masegi T, Nakai Y. Morphological and immunohistochemical features of Cryptosporidium andersoni in cattle. Vet Pathol 2006; 43:202-207
  9. Ritchie BW, Harrison GJ, Harrison LR. Avian Medicine: Principles and Application. Lake Worth, FL:Wingers Publishing, Inc.;1994:1016-1017.
  10. Saif, YM. Cryptosporidiosis. In: ed. Saif YM, Diseases of Poultry. 12th ed., Ames, IA:Blackwell; 2008:1085-90.
  11. Trees AJ. Parasitic disease. In: eds. Pattison M, McMullin PF, Bradbury JM, Alexander DJ, Poultry Disease. 6th ed., Philadelphia, PA: Elsevier; 2008:457-8.
  12. Taylor MA, Coop RL., Wall RL. Veterinary Parasitology. 4th ed., Cambridge, MA:Blackwell Science, Inc.; 2016:139,718-719.
  13. Uzal FA., Plattner BL., Hostetter JM. Alimentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. Philadelphia, PA: Elsevier; 2016:239-241.

 


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