JPC SYSTEMIC PATHOLOGY
SPECIAL SENSES SYSTEM
May 2018
S-N05 (NP)

Signalment (JPC # 844012):  Cat

HISTORY:  Tissue from a cat with exophthalmus because of progressive retrobulbar swelling beginning in the zygomatic arch.

HISTOPATHOLOGIC DESCRIPTION:  Lacrimal gland, conjunctiva and retrobulbar skeletal muscle:  Expanding the lacrimal gland, infiltrating the conjunctival sub epithelial connective tissue and extending to the cut border is an unencapsulated, densely cellular, multilobular neoplasm that is subdivided by narrow bands of dense fibrous connective tissue. Neoplastic polygonal cells are arranged in cords, tubulopapillary projections and acinar structures, on a prominent basement membrane, and that frequently palisade along a moderate fibrovascular stroma. Neoplastic cells have variably distinct cell borders, a moderate amount of finely vacuolated to eosinophilic, granular cytoplasm and one irregularly round to oval, often basally located nucleus, with finely stippled chromatin and 1-2 nucleoli. There is mild anisokaryosis and anisocytosis. The mitotic count is 1-2 per 10 HPF. Multifocally, the surrounding fibroadipose tissue and ocular muscle are expanded by edema, hemorrhage and few lymphocytes and plasma cells.

MORPHOLOGIC DIAGNOSIS: Lacrimal gland, conjunctiva and retrobulbar skeletal muscle: Lacrimal gland adenocarcinoma, breed unspecified, feline.

GENERAL DISCUSSION:

TYPICAL CLINICAL/GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

References:

  1. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. 4th Ames, IA: Wiley-Blackwell; 2016:114.
  2. Dubielzig RR, Ketring KL, McLellan GJ, et al. eds. Veterinary Ocular Pathology: A Comparative Review. St. Louis, MO: Elsevier Saunders; 2010: 134, 137.
  3. Gelatt KN, Plummer CE. Color Atlas of Veterinary Ophthalmology. 2nd Ames, IA: Wiley Blackwell; 2017: 63, 98, 103
  4. Labelle P. The eye. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Elsevier; 2017: 1273, 1295-1297
  5. Miyazaki A, Yonemaru K, Hirata A, et al. Histopathological and immunohistochemical features of atypical epithelial tumours of the gland of the third eyelid in seven dogs. J Comp Pathol. 2015; 152(4): 299-303
  6. Wang FI, Ting CT, Liu YS. Orbital adenocarcinoma of lacrimal gland origin in a dog. J Vet Diagn Invest. 2001; 13(2): 159-161.
  7. Wilcock BP, Njaa BL. Special senses. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th St. Louis, MO: Elsevier; 2016: 482


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