JPC SYSTEMIC PATHOLOGY
REPRODUCTIVE SYSTEM
January 2019
R-N06

Signalment (JPC #2329087):  9-year-old maned wolf (Chrysocyon brachyurus).

HISTORY:  Abdominal mass

HISTOPATHOLOGIC DESCRIPTION:  Ovary (per contributor):  Diffusely replacing normal architecture and entrapping or compressing rare remaining ovarian follicles is a poorly circumscribed, unencapsulated, densely cellular neoplasm composed of round cells arranged in sheets and occasional cords which are separated by a scant fibrous connective tissue stroma.  Neoplastic cells have distinct cell borders and small to moderate amounts of eosinophilic granular to vacuolated cytoplasm.  Nuclei are large, centrally placed, irregularly round, and vesiculate with 1-2 prominent magenta nucleoli.  There is moderate anisokaryosis and anisocytosis, and mitoses average 3 per HPF.  Neoplastic cells are occasionally multinucleated or contain large pleomorphic nuclei.  There is multifocal individual cell necrosis, scattered hemorrhage and rare cystic areas filled with homogenous eosinophilic proteinaceous fluid.  Focally the neoplastic cells extend through the tunica albuginea into the surrounding adipose tissue.

MORPHOLOGIC DIAGNOSIS:  Ovary (per contributor):  Dysgerminoma, maned wolf (Chrysocyon brachyurus), canine.

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTICS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Agnew DW, MacLachlan NJ. Tumors of the genital systems. In: Meuten, DJ, ed. Tumors in Domestic Animals. 5th ed. Ames, IA: John Wiley & Sons, Inc.; 2017:698.
  2. Brazzell JL, Borjesson DL. Intra-abdominal mass aspirate from an alopecic dog. Vet Clin Pathol. 2006;35(2):259-262.
  3. Ellenson LH, Pirog EC. The female genital tract. In: Kumar VK, Abbas AK, Fausto N, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2015:1030-1031.
  4. Fitzgerald SD, Duncan AE, Tabaka C, Garner MM, Dieter A, Kiupel M. Ovarian dysgerminomas in two mountain chicken frogs (Leptodactylus fallax). J Zoo Wildlife Med. 2007;38(1):150-153.
  5. Gardner GR, Yevich PP, Hurst J, Thayer P, Benyi S, Harshbarger JC, Pruell RJ. Germinomas and teratoid siphon anomalies in softshell clams, Mya arenaria, environmentally exposed to herbicides. Environ Health Perspect.1991;90:43-51.
  6. Hara S, Morita R, Shiraki , Segawa R, et al. Expression of protein gene product 9.5 and Sal-like protein 4 in canine seminomas.  J Comp Path. 2014; 151:10-18.
  7. Jafarey YS, Berlinski RA, Hanley CS, Garner MM, Kiupel M. Presumptive dysgerminoma in an orange-spot freshwater stingray (Potamotrygon motoro). J Zoo Wildl Med. 2015;46(2):382-385.
  8. Munson L, Montali RJ. High prevalence of ovarian tumors in maned wolves (Chrysocyon brachyurus) at the National Zoological Park. J Zoo Wildlife Med. 1991;22(1):125-129.
  9. Schlafer DH, Foster RA. Female genital system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier; 2016:377-379.
  10. Strunk A, Imai DM, Osofsky A, Tell LA. Dysgerminoma in an Eastern Rosella (Platycercus eximius eximius).  Avian Diseases. 2011;55:133-138.


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