JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
October 2018
D-P09

Signalment (JPC #1640180):  Moustached tamarin (Saguinus mystax)

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Ileum, two sections: Focally disrupting and expanding the submucosa and tunica muscularis elevating the overlying ulcerated mucosa is a 5mm nodule that contains a central cavity with a 1 X 1.75 mm cross section of an adult acanthocephalid, characterized by a thin outer cuticle and a thick hypodermis (up to 150 um) composed of an outer felted layer and cross fibers containing lacunae, outer circular and inner longitudinal muscle layers, and a pseudocoelom containing lemnisci with compressor muscles.  The parasite is surrounded by a thin layer of degenerate neutrophils and eosinophils, which are further surrounded by a zone of epithelioid macrophages, neutrophils, eosinophils, lymphocytes and plasma cells that are enmeshed in thick concentric bands of mature fibrous connective tissue and fibroblasts (pyogranuloma).  Fibrous connective tissue within the submucosa is multifocally and mildly separated by increased clear space (edema) and a mixed population inflammatory cells, which occasionally form aggregates.  Associated with one cross section of an acanthocephalid adult is a focal area of mucosal ulceration characterized by loss and replacement of enterocytes by karyorrhectic and cellular debris and degenerate neutrophils. 

MORPHOLOGIC DIAGNOSIS:  Ileum:  Enteritis, pyogranulomatous, chronic, focal, moderate, with focal ulceration, and adult acanthocephalid parasites, moustached tamarin (Saguinus mystax), nonhuman primate.

ETIOLOGIC DIAGNOSIS:  Intestinal acanthocephaliasis

CAUSE:  Prosthenorchis elegans

GENERAL DISCUSSION:

PATHOGENESIS:

LIFE CYCLE:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Gardiner CH, Poynton SL. An Atlas of Metazoan Parasites in Animal Tissues, American Registry of Pathology. Washington, DC, 1999:44-45.
  2. Strait K, Else JG, Eberhard ML. Parasitic disease of nonhuman primates. In: Abee CR, Mansfield K, Tardif S, Morris T, eds. Nonhuman Primates in Biomedical Research. Vol 2. Diseases. 2nd ed. San Diego, CA: Elsevier, Inc. 2012: 258-260.
  3. Uzal FA, Plattner BL, Hostetter JM. Alimentary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier Ltd; 2016:116, 227.


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