JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

October 2017

P-V08

 

Signalment (JPC #1492980):  3-month-old cat

HISTORY:  Section of lung from a cat killed two days after aerosol infection with an experimental agent.

 HISTOPATHOLOGIC DESCRIPTION:  Lung:  There is consolidation and atelectasis affecting approximately 70% of the lung.  Within areas of consolidation, alveolar septa are fragmented, discontinuous and replaced by fibrin and eosinophilic cellular and karyorrhectic debris (septal necrosis), lined by hyperplastic cuboidal epithelium (type II pneumocyte hyperplasia) or expanded up to 8 times normal by fibrin, edema, neutrophils and macrophages.  Alveolar, and to a lesser extent bronchiolar and bronchial lumina are filled with variable amounts of fibrin, edema, hemorrhage, eosinophilic cellular and karyorrhectic debris (necrosis), neutrophils and alveolar macrophages.  There is bronchiolar epithelial hyperplasia.  Multifocally, blood vessels are lined by plump endothelial cells (reactive endothelium).  There is perivascular edema and hemorrhage and the pleura is mildly thickened by fibrin and hemorrhage.

MORPHOLOGIC DIAGNOSIS:  Lung:  Pneumonia, interstitial, necrotizing, focally extensive, marked, with type II pneumocyte hyperplasia, breed unspecified, feline.

ETIOLOGIC DIAGNOSIS:  Caliciviral pneumonia

CAUSE:  Feline calicivirus (FCV)

GENERAL DISCUSSION:

 PATHOGENESIS:

 TYPICAL CLINICAL FINDINGS:

 TYPICAL GROSS FINDINGS: 

 TYPICAL LIGHT MICROSCOPIC FINDINGS:

 ULTRASTRUCTURAL FINDINGS

 ADDITIONAL DIAGNOSTIC TESTS:

 DIFFERENTIAL DIAGNOSIS:

Feline respiratory diseases:

 COMPARATIVE PATHOLOGY: 

 References:

  1. Caswell JL, Williams KJ. Respiratory system. In: Maxie MG, ed. Jubb, Kennedy, Palmer's Pathology of Domestic Animals. Vol. 2. 6th ed. Philadelphia, PA: Elsevier; 2016:589.
  2. Gaskell R, Dawson S, Radford A. Feline Respiratory Disease. In: Greene CE, ed. Infectious Diseases of the Dog and Cat. 4th ed. St Louis, MO: Elsevier; 2012:151-162.
  3. Lala VM, Benassi JC, Bisetto SP, et al. Molecular Detectin of Inectious Pathogens of the Upper respiratory Tract in Captive Nondomestic Felids. J Zoo Wildl Med. 2017 Jun;48:529-531.
  4. Lenghaus C, Studdert MJ, Gavier-Widen D. Calicivirus Infections. In: Williams ES, Barker IK, eds. Infectious Diseases of Wild Mammals. 3rd ed. Ames, IA: Iowa State University Press; 2001:280-291.
  5. Munson L, Wack R, Duncan M, et al. Chronic Eosinophilic Dermatitis Associated with Persistent Feline Herpes Virus Infection in Cheetahs (Acinonyx jubatus). Vet Pathol. 2004;41(2):170-176.
  6. Pesavento PA, MacLachlan NJ, Dillard-Telm L, Grant CK, Hurley KF. Pathologic, Immunohistochemical, and Electron Microscopic Findings in Naturally Occurring Virulent Systemic Feline Calicivirus Infection in Cats. Vet Pathol. 2004;41(3):257-263.
  7. Pesavento PA, Stokol T, Liu H, van der List DA, Gaffney PM, Parker JS. Distibution of the Feline Calicivirus Receptor Junctional Adhesion Molecule A in Feline Tissues. Vet Pathol. 2011;48(2):361-368.
  8. Stiles J. Ocular Infections. In: Greene CE, ed. Infectious Diseases of the Dog and Cat. 4th ed. St Louis, MO: Elsevier; 2012:1060-1063.
  9. Van Bonn WG. Pinnipdia, Disease. In: Fowler ME, Miller RE eds. Zoo and Wild Animal Medicine. 8nd ed. Philadelphia, PA: WB Saunders, Co. 2015:446.

 

 


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