JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
January 2018
U-N03

Signalment (JPC #1667565):  1‑year‑old male Doberman pinscher

HISTORY:  Hematuria for six months

HISTOPATHOLOGIC DESCRIPTION:  Urinary bladder:  Infiltrating and replacing the subepithelial connective tissue and elevating the overlying markedly hyperplastic and multifocally ulcerated epithelium is a 1 x 2 cm, unencapsulated, poorly circumscribed, infiltrative, multilobular, variably dense, polypoid neoplasm composed of spindle cells arranged in interlacing streams and bundles separated by scant eosinophilic fibrillar matrix.  Neoplastic cells are most dense beneath the mucosa (cambium layer) and less dense at the deeper aspects with few neoplastic cells embedded in a myxomatous matrix.  Neoplastic cells have variably distinct cell borders, moderate to abundant eosinophilic fibrillar cytoplasm, oval to elongate nuclei containing coarsely stippled chromatin, and small indistinct nucleoli.  The mitotic rate averages 1 per 10 HPF’s.  There are scattered, large, rectangular multinucleated neoplastic cells with tandem peripheralized nuclei and prominent cross striations (strap cells).  The mucosa is diffusely hyperplastic with formation of papillary projections or has areas of ulceration and hemorrhage.  There is multifocal submucosal edema with moderate numbers of neutrophils.

MORPHOLOGIC DIAGNOSIS:  Urinary bladder: Botryoid rhabdomyosarcoma, Doberman pinscher, canine.

GENERAL: 

PATHOGENESIS

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

Actin and myosin filaments, polyribosomes, Z-bands, and mitochondria are prominent in botryoid RMS, laryngeal muscle tumors (both rhabdomyomas and RMS), and RMS that is not further classified (RMS not otherwise specified [NOS])

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Agnew DW, MacLachlan J. Tumors of the genital systems. In: Meuten DJ ed. Tumors in Domestic Animals. 5th ed. Ames, Iowa: Iowa State Press; 2017:693.
  2. Avallone G, Pinto da Cunha N, Palmieri C. Subcutaneous embryonal rhabdomyosarcoma in a dog: cytologic, immunocytochemical, histologic, and ultrastructural features. Vet Clin Pathol. 2010; 39(4):499-504.
  3. Breshears MA, Confer AW. The urinary system. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Mosby/Elsevier; 2017:671.
  4. Caserto BG. A comparative review of canine and human rhabdomyosarcoma with emphasis on classification and pathogenesis.  Vet Pathol. 2013; 55(5):806-826.
  5. Castleman WL, Toplon DE, Clark CK. Rhabdomyosarcoma in 8 horses. Vet Pathol. 2011; 48(6):1144-50.
  6. Cianciolo RE and Mohr FC. Urinary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. 6th ed.Vol 2. Philadelphia, PA: Elsevier Ltd; 2016:462-464.
  7. Cooper BJ, Valentine BA. Muscle and tendon. In: Maxie MG ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. 6th ed., Vol. 1. Saunders Elsevier, Philadelphia, PA, 2016:241-243.
  8. Cooper BJ, Valentine BA: Tumors of muscle. In: Meuten DJ, ed. Tumors in Domestic Animals. 5th ed. Ames, Iowa: Iowa State Press; 2017:444-466.
  9. LaDouceur EB, Stevens SE, et al. Immunoreactivity of cainine liposarcoma to muscle and brown adipose antigens. Vet Pathol. 2017; 54(6); 885-891.
  10. Lohr CV. One hundred two tumors in 100 goats (1987–2011). Vet Pathol. 2012; 50(4): 668-675.
  11. Meuten DJ, Everitt J, Inskeep W et al. Histological classification of tumors of the urinary system of domestic animals. In: Schulman FY, ed. World Health Organization International Histological Classification of Tumors of Domestic Animals. Vol XI. 2nd ed. Washington, DC: Armed Forces Institute of Pathology; 2004:33-34.
  12. Murakami M, Sakai H, Iwatani N, et al. Cytologic, histologic, and immunohistochemical features of a maxillofacial alveolar rhabdomyosarcoma in a juvenile dog. Vet Clin Pathol. 2010; 39(1):113-8.
  13. Rehg JE, Ward JM. Morphological and immunohistochemical characterization of sarcomatous tumors in wild-type and genetically engineered mice. Vet Pathol. 2012; 49(1):206-17.
  14. Sirri R, Bianco C, et al. Rhabdomyosarcoma of the soft tissues in an adult brook trout (Salvelinus fontinalis). J Comp Pathol. 2015; 153:190-195.

 

 


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