JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

September 2017

P-M07 (NP)

 

Signalment (JPC #2142217):  Adult female chinchilla

HISTORY:  This chinchilla died due to bacterial septicemia

HISTOPATHOLOGIC DESCRIPTION:  Lung:  Multifocally, alveolar septal capillaries are expanded and occluded by polygonal cells that are up to 150 um diameter with abundant amphophilic granular cytoplasm, nuclei that  are 25-45 um in diameter with reticular chromatin, and 1-2 irregularly shaped to oval magenta nucleoli (placental trophoblasts).  Few trophoblasts are binucleate. 

MORPHOLOGIC DIAGNOSIS: 

Lung, septal capillaries:  Trophoblastic emboli, multifocal, mild.

ETIOLOGIC DIAGNOSIS:  Trophoblastic embolism

GENERAL DISCUSSION: 

 

Species

Distribution of contact

Classification by maternal cell layers

Maternal-fetal interdigitation

Mare, Sow

Diffuse

Epitheliochorial

Villi (horse: “cups”, pig: folded villi)

Ruminant

Cotyledonary

(Syn)epitheliochorial (combination)

Villi

Bitch, Queen

Zonary

Endotheliochorial

Labyrinth

Rhesus macaque

Double discoid

Hemochorial

Villi

Ape, human

Discoid

Hemochorial

Villi

Rabbits, rodents

Discoid

Hemochorial

Labyrinth

 

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, IA: Blackwell Publishing; 2016: 174, 200.
  2. Burek JD, Goldberg B, Hutchins G, Strandberg JD. The pregnant Syrian hamster as a model to study intravascular trophoblasts and associated maternal blood vessel changes. Vet Pathol. 1979;5:556‑566.
  3. Hamir AN, Rupprecht. Trophoblast-like cells in the tissues of porcupines (Erethizoon dorsatum). Vet Pathol. 2008;45:409-411.
  4. La Perle KM, Green MG, Niewiesk S. Trophoblast deportation to the lungs of cotton rats (Sigmodon hispidus).  Comp Med 2014;64(6):448-55.
  5. Noden DM, De Lahunta A. The Embryology of Domestic Animals: Developmental Mechanisms and Malformations. Baltimore, MD: Williams and Wilkins;1985:50‑69.
  6. Suckow MA, Stevens KA, Wilson RP. The Laboratory rabbit, guinea pig, hamster, and other rodents.  London, UK: Academic Press;2012:1005.
  7. Tvedten HW, Langham RF. Trophoblastic emboli in a chinchilla. J Am Vet Med Assoc. 1974;165:828-829.


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