JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
September 2018
D-M04

SIGNALMENT (JPC # 2316884):  A young New Zealand white rabbit

HISTORY:  The animal was depressed, displayed a crouched stance, grinding of the teeth, thin conformation, bloated abdomen and had diarrhea.

HISTOPATHOLOGIC DESCRIPTION:  Colon: The colon is markedly distended and contains abundant amphophilic flocculent material (mucus) within the lumen. The mucosal epithelium is diffusely thickened by an increase in thickness of crypts which contain variable amounts of mucus are tightly packed, tortuous, and lined by numerous hypertrophied goblet cells (goblet cell hyperplasia).

MORPHOLOGIC DIAGNOSIS:  Colon:  Goblet cell hyperplasia, diffuse, severe, with luminal distension by abundant mucus accumulation, New Zealand white rabbit, lagomorph.

CONDITION:  Mucoid enteropathy (ME)

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:  Diagnosis is based on clinical signs and characteristic gross and microscopic features

COMPARATIVE PATHOLOGY:  ME has similarities to human cystic fibrosis, a disease of defective electrolyte transport that causes excessive mucus production by intestines, pancreatic and bile ducts, and respiratory epithelium

REFERENCES:

  1. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, IA: Blackwell Publishing; 2016:306-307.
  2. Haligur M, Ozmen O, Demir N. Pathological and ultrastructural studies on mucoid enteropathy in New Zealand rabbits. JEPM. 2009; 18:224-228.
  3. Hotchkiss CE, Merritt AM. Mucus secretagogue activity in cecal contents of rabbits with mucoid enteropathy. Lab Anim Sci.1996; 46:179-186.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |