JPC SYSTEMIC PATHOLOGY
URINARY
February 2018
U-V09

Signalment (AFIP #2329759):  2-year-old male rhesus monkey

HISTORY:  This 2-year-old male rhesus monkey was born at the primate center and entered in a study of simian immunodeficiency virus pathogenesis.  He was inoculated with SIVmac251 and died 1 year later.

HISTOPATHOLOGIC DESCRIPTION:  Kidney:  Diffusely and moderately expanding the cortical interstitium, loosely arranged fibrous connective tissue, scattered individual and rare aggregates of lymphocytes and plasma cells surround and separate tubules, which are often atrophic in areas of fibrosis.  Tubules are multifocally ectatic and/or contain pale eosinophilic granular material (protein) or few sloughed epithelial cells.  Tubules are often lined by enlarged epithelial cells that appear multiple layers deep (hypertrophy and hyperplasia). Multifocally, tubular epithelium is attenuated (flattened), degenerate (swelling and cytoplasmic vacuolization), necrotic (shrunken with karyolytic and pyknotic nuclei), or regenerative (basophilic cells with large vesiculate nuclei).  Multifocally low numbers of 6-8 um, round to angular, basophilic intranuclear viral inclusion bodies are present within tubular epithelial cells and the parietal epithelial cells of Bowman’s capsule. Focally, glomeruli have hypertrophic parietal and visceral epithelial cells and occasionally exhibit synechia (adherence to Bowman’s capsule).

MORPHOLOGIC DIAGNOSIS:  Kidney:  Nephritis, tubulointerstitial, lymphocytic, chronic, diffuse, moderate, with tubular degeneration, necrosis, and regeneration, moderate interstitial fibrosis, and epithelial intranuclear viral inclusion bodies, Rhesus monkey (Macaca mulatta), primate.

ETIOLOGIC DIAGNOSIS:  Polyomaviral nephritis

CAUSE:  Simian virus 40

SYNONYMS: 

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:  Viruses causing inclusion bodes can be differentiated based on size, using electron microscopy, or antigenic or genetic composition using virus-specific immunohistochemistry

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. 4th ed Ames, IA: John Wiley & Sons, Inc; 2016:176-177.
  2. Cummins Macri S, Knight HL, Miller AD. Mesenchymoproliferative Enteropathy Associated With Dual Simian Polyomavirus and Rhesus Cytomegalovirus Infection in a Simian Immunodeficiency Virus–Infected Rhesus Macaque (Macaca mulatta). Vet Pathol. 2013; 50(4):715-721.
  3. Fahey MA, Westmoreland SV. Nervous System Disorders of Nonhuman primates and Research Models. In: Abee CR, Mansfield K, Tardif S, Morris T, eds. Nonhuman primates in biomedical research: Diseases. Vol 2. 2nd ed. London, UK: Elsevier; 2012:739-740.
  4. Giannitti F, Higgins RJ, Pesavento PA, et al.Temporal and geographic clustering of polyomavirus-associated olfactory tumors in 10 free-ranging raccoons (Procyon lotor). Vet Pathol. 2014 ;51(4):832-45.
  5. Jennings SH, Wise AG, Nickeleit V et al. Polyomavirus-associated nephritis in 2 horses. Vet Pathol.  2013; 50(5): 769-774.
  6. Wachtman L, Mansfield K. Viral diseases. In: Abee CR, Mansfield K, Tardif S, Morris T, eds. Nonhuman Primates in Biomedical Research: Diseases. Vol 2. 2nd ed. London, UK: Elsevier;2012:30-33.


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