JPC SYSTEMIC PATHOLOGY
HEMOLYMPHATIC SYSTEM
April 2018
H-V11

Signalment (JPC #10893-97):  Pig

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Lymph node:  Diffusely there is lymphoid depletion, with a paucity of lymphoid follicles and decreased lymphocyte denstiy.  Approximately 80% of the cortex and medulla is replaced by multifocal to coalescing, densely cellular aggregates of epithelioid macrophages with abundant eosinophilic cytoplasm and fewer multinucleate giant cells with up to 20 nuclei that are located either along the cell periphery (Langhans type) or within the center (foreign body type), admixed with moderate numbers of eosinophils.  Occasionally macrophages and multinucleate giant cells contain clusters of 4 - 8 µm diameter, eosinophilic-basophilic globular intracytoplasmic viral inclusions (botryoid inclusion bodies).

MORPHOLOGIC DIAGNOSIS:  Lymph node:  Lymphadenitis, granulomatous, multifocal to coalescing, marked, with lymphoid depletion and intrahistiocytic intracytoplasmic eosinophilic botryoid viral inclusion bodies, breed unspecified, porcine.

ETIOLOGIC DIAGNOSIS:  Porcine circoviral lymphadenitis

CAUSE:  Porcine circovirus type 2 (PCV2)

CONDITION:  Postweaning multisystemic wasting syndrome

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

For histologic lesion of lymphoid depletion in lymph nodes:

COMPARATIVE PATHOLOGY:

Other important circoviruses include:

REFERENCES:

  1. Brown DL, Van Wettere AJ, Cullen JM. Hepatobiliary system and exocrine pancreas. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Elsevier; 2017: 441
  2. Cantile C, Youssef S. Nervous system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th St. Louis, MO: Elsevier; 2016:382-383
  3. Caswell JL, Williams KJ. Respiratory system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th St. Louis, MO: Elsevier; 2016:527-529
  4. Cianciolo RE, Mohr FC. Urinary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th St. Louis, MO: Elsevier; 2016:412-413
  5. Foster RA. Female Reproductive System and Mamma. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Elsevier; 2017: 1188
  6. Galindo-Cardiel I, Grau-Roma L, Perez-Maillo M, et al. Characterization of necrotizing lymphadenitis associated with porcine circovirus type 2 infection. J Comp Pathol. 2011; 144:63-69.
  7. Gillespie J, Opriessnig T, Meng XJ, et al. Porcine circovirus type 2 and porcine circovirus-associated disease. J Vet Intern Med. 2009; 23: 1151-1163.
  8. Hansen MS, J. Segale´ J, Fernandes LT, et al. Detection of porcine circovirus type 2 and viral replication by in situ hybridization in primary lymphoid organs from naturally and experimentally infected pigs. Vet Pathol. 2013; 50(6):980-988
  9. Huanh YY, Walther I, Martinson SA, et al. Porcine circovirus 2 inclusion bodies in pulmonary and renal epithelial cells. Vet Pathol. 2008; 45: 640-644.
  10. Konradt G, Cruz RA, Bassuino DM, et al. Granulomatous necrotizing myositis in swine affected by porcine circovirus disease. Vet Pathol. 2018; 55(2):268-272
  11. Langohr IM, Stevenson GW, Nelson EA, et al. Vascular lesions in pigs experimentally infected with porcine circovirus type 2 serogroup B. Vet Pathol. 2010; 47:140-147.
  12. López A, Shannon A. Martinson SA. Respiratory system, mediastinum, and pleurae. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Elsevier; 2017: 541
  13. Opriessnig T, Langohr I. Current state of knowledge on porcine circovirus type 2-associated lesions. Vet Pathol. 2013; 50(1):23-38.
  14. Resendes AR, Segalés J. Characterization of vascular lesions in pigs affected by porcine circovirus type 2-systemic disease. Vet Pathol. 2015; 52(3):497-504
  15. Schlafer DH, Foster RA. Female genital system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th St. Louis, MO: Elsevier; 2016:440
  16. Seeliger FA, Bruegmann ML, Krueger L, et al. Porcine circovirus type 2-associated cerebellar vasculitis in postweaning multisystemic wasting syndrome (PMWS)-affected pigs. Vet Pathol. 2007; 44:621-634.
  17. Uzal FA, Plattner BL, Hostetter JM. Alimentary system In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th St. Louis, MO: Elsevier; 2016:116
  18. Valli VEO, Kiupel M, Bienzle D. Hematopoietic System In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th St. Louis, MO: Elsevier; 2016:210-212
  19. Zachary JF. Mechanisms of microbial infections. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Elsevier; 2017: 219-220


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