JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

September 2017

P-P07

 

Signalment (JPC #1642875): Cat

HISTORY: None

HISTOPATHOLOGIC DESCRIPTION: Lung: Effacing and replacing up to 30% of the section are multifocal to coalescing nodular aggregates of numerous macrophages and fewer lymphocytes, plasma cells, neutrophils, eosinophils with abundant fibrous connective tissue and minimal hemorrhage that surround an adult trematode and eggs.  The adult trematode is 2x3 mm, has a 40 um thick spiny tegument, and a spongy parenchyma that contains numerous subtegumental vitellaria with eosinophilic globular yolk material.  Trematode eggs are 80 x 100um, and have a 1‑3um thick, yellow, anisotropic shell.  In less affected areas there are pigment laden macrophages, lymphoid aggregates and hemorrhage. Multifocally, bronchial and bronchiolar lumena are filled with sloughed epithelial cells, low numbers of macrophages, neutrophils, lymphocytes and plasma cells.  There is multifocal bronchiolar and alveolar smooth muscle hypertrophy, as well as hyperplasia of peribronchial mucous glands.  Multifocally the tunica media of small and medium blood vessels is thickened by smooth muscle hypertrophy, and there is endothelial hypertrophy and vacuolation.  The pleura is thickened 2-3 times normal by lymphocytes, plasma cells, macrophages, fibrous connective tissue, and hypertrophic (reactive) cuboidal mesothelial cells.  

MORPHOLOGIC DIAGNOSIS:  Lung:  Pneumonia, granulomatous, nodular, chronic, multifocal, moderate, with fibrosis, pleuritis and adult trematodes and eggs, etiology consistent with Paragonimus sp., breed unspecified, feline.

ETIOLOGIC DIAGNOSIS: Pulmonary paragonimiasis

CAUSE: Paragonimus kellicotti

GENERAL DISCUSSION:

PATHOGENESIS

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Bowman DD. Helminths. In: Georgis’ Parasitology for Veterinarians. 10th ed, St. Louis, MO: WB Saunders; 2014:410-412.
  2. Caswell JL, Williams KJ. Respiratory System. In: Maxie ME, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. 6th ed. Vol 2, Philadelphia, PA: Elsevier; 2016:591.
  3. Gardiner CH, Poyton SL. An Atlas of Metazoan Parasites in Animal Tissue. Washington, DC: Armed Forces Institute of Pathology; 1990:46-48.
  4. Lopez A, Martinson SA. Respiratory system, mediastinum, and pleurae. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St Louis, MO: Elsevier; 2017:548,551, 556.
  5. Urquhart GM, Armour J, Duncan JL, Dunn AM, et al. Veterinary Parasitology. 2nd ed. Blackwell Science LTD: Oxford, England; 1996:116-117.

 

 


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