JPC SYSTEMIC PATHOLOGY
HEMOLYMPHATIC SYSTEM
March 2018
H-B04

Signalment (JPC#1577423):  Three-year-old blesbok

HISTORY:  Tissue from a three-year-old blesbok (African ruminant) that developed an acute illness and died.

HISTOPATHOLOGIC DESCRIPTION:  Lymph node:  Approximately 80% of nodal architecture is replaced by multifocal to coalescing areas of lytic necrosis, characterized by loss of tissue architecture, and replacement by abundant eosinophilic cellular and karyorrhectic debris, admixed with numerous degenerate neutrophils, abundant eosinophilic beaded material (fibrin), and numerous large, up to 250 um diameter, botryoid colonies of densely packed, 1 x 2 um, basophilic coccobacilli.  Diffusely, remaining medullary cords and sinuses are expanded by moderate numbers of foamy macrophages, which often contain phagocytized cellular debris and erythrocytes (erythrophagocytosis), and fewer plasma cells.  Multifocally, there are large areas of hemorrhage, and diffusely, there is moderate congestion of blood vessels.  The previously described inflammatory cells, hemorrhage, and fibrin multifocally extend into and expand the capsule and perinodal adipose tissue.

MORPHOLOGICAL DIAGNOSIS:  Lymph node:  Lymphadenitis, necrosuppurative, subacute, diffuse, severe, with hemorrhage and numerous large colonies of coccobacilli, blesbok (Damaliscus dorcas), artiodactyl.

ETIOLOGIC DIAGNOSIS:  Yersinial lymphadenitis

CAUSEYersinia pseudotuberculosis

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

Bacteria that appear histologically as large colonies:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Brogden KA. Cytopathology of pathogenic prokaryotes. In: Cheville NF, ed.  Ultrastructural Pathology:  The Comparative Cellular Basis of Disease. 2nd ed.  Ames, IA: Wiley-Blackwell; 2009:475-476.
  2. Brown DL, Wettere AJV, Cullen JW. Hepatobiliary system and exocrine pancreas. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Mosby Elsevier; 2017:444.
  3. Gasper PW, Watson RP. Plague and yersiniosis.  In: Infectious Diseases of Wild Mammals.  3rd ed. Ames, IA: Iowa State University Press; 2001:323-329.
  4. Giannitti F, Barr BC, Brito BP, Uzal FA, Villanueva M, Anderson M. Yersinia pseudotuberculosis infections in goats and other animals diagnosed at the California Animal Health and Food Safety Laboratory System: 1990-2012. J Vet Diagn Invest. 2014; 26(1):88-95.
  5. Giles C, Boerlin P. Horizontally transferred genetic elements and their role in pathogenesis of bacterial disease. Vet Pathol. 2014; 51(2):328-340.
  6. Nakamura S, Hayashidani H, Okabe N, Une Y. Aberrant forms of Yersinia pseudotuberculosis as spheroplasts and filaments in yersiniosis in squirrel monkeys.  Vet Pathol. 2015; 52(2):393-396.
  7. Nakamura A, Settai S, Hayashidani H, Urabe T, Namai S, Une Y. Outbreak of yersiniosis in Egyptian rousette bats (Rousettus aegyptiacus) caused by Yersinia pseudotuberculosis serotype 4b. J Comp Pathol. 2013; 148(4):410-413.
  8. Percy DH, Barthold SW. Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, IA: Blackwell Publishing; 2016: 186, 230-231, 288.
  9. Sasseville VG. Meeting report:  Primates and in nonhuman primate species used in drug safety studies meeting report: Spontaneous lesions and diseases in wild, captive-bred, and zoo-housed nonhuman primates.  Vet Pathol.  2012; 49(6):1057.
  10. Shin-ichi N, Hayashidani H, et al. Yersiniosis due to infection by Yersinia pseudotubculosis 4b in captive meerkats (Suricata suricatta) in Japan. J Vet Diagn Invest. 2015; 27(5):641-644.
  11. Taylor DJ. Miscellaneous bacterial infections.  In: Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW, eds. Diseases of Swine. 10th ed. Ames, IA: Blackwell Publishing; 2012:879-881.
  12. Valli VEO, Kiupel M, Bienzle H. The hematopoietic system. In: Maxie MG, ed. Jubb Kennedy and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:209-210.
  13. Wessels ME, Payne JH, Bannerman RP. Oculoglandular syndrome caused by Yersinia pseudotuberculosis in a dairy goat. J Comp Pathol. 2009; 141(2-3):190-194.
  14. Uzal FA, Plattner BL, Hostetter JM. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. Philadelphia, PA: Elsevier; 2016:176-177.

 

 

 

 


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