JPC SYSTEMIC PATHOLOGY
Urinary System
December 2017
U-B05 (NP)

Signalment: (JPC #1376954):  Unknown gender, young calf

HISTORY:  Incidental finding at post mortem in a young calf.

HISTOPATHOLOGIC DESCRIPTION:  Kidney:  Multifocally and randomly expanding the subcapsular cortical interstitium, up to 2mm in diameter, extending to the corticomedullary junction, and surrounding, separating, and infiltrating glomeruli and renal tubules are moderate numbers of lymphocytes with fewer plasma cells, macrophages and neutrophils.   Inflammatory cells are admixed with edema, fibrin and variable numbers of reactive fibroblasts and collagen bundles which multifocally replace tubules and glomeruli.  Renal tubular epithelium within these foci often exhibits one of the following changes:  atrophy, degeneration (characterized by pale, swollen, vacuolated epithelial cells), necrosis (characterized by shrunken cells with hypereosinophilic cytoplasm and pyknotic nuclei), or regeneration (characterized by large epithelial cells with basophilic cytoplasm, prominent vesiculate nuclei, and increased numbers of mitotic figures).  Affected tubules are occasionally ectatic, lined by attenuated epithelium, and contain intraluminal granular eosinophilic material, or occasionally are filled with degenerate neutrophils, sloughed epithelial cells and eosinophilic cellular and karyorrhectic debris (necrosis). Multifocally throughout the section, lymphatic vessels are ectatic..

MORPHOLOGIC DIAGNOSIS: Kidney, cortex:  Nephritis, interstitial, lymphoplasmacytic, neutrophilic, and histiocytic, chronic, multifocal, moderate, with tubular atrophy, degeneration, necrosis, regeneration, and interstitial fibrosis, breed unspecified, bovine.

CAUSE:  Usually undetermined; Escherichia coli can occasionally be recovered from the lesions, but other suggested etiologies include Salmonella sp., Brucella sp., and Leptospira sp.

CONDITION:  White-spotted kidneys of calves

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS: 

Multifocal interstitial nephritis in cattle:

COMPARATIVE PATHOLOGY:

For interstitial nephritis:

For embolic suppurative nephritis:

References:

  1. Breshears MA, Confer AW. The urinary system. In: Zachary JF, ed. Pathological Basis of Veterinary Disease. 6th ed. Philadelphia, PA: Mosby Elsevier Inc.; 2017:632-632; 673-674.
  2. Cianciolo RE, Mohr FC. Urinary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:431,436.
  3. Uzal FA, Dobrenov B, Smythe L, et.al. A study of "white spotted kidneys" in cattle. Vet Microbiol. 2002;86:369-375.


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