JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

September 2014

P-P05

 

Signalment (JPC 4068027-00): Tissue from a cat.

HISTORY: Three year old, stray, male, domestic shorthair cat became lethargic, bradycardic and hypothermic, and then died within 48 hours of being neutered.

HISTOPATHOLOGIC DESCRIPTION: Lung: Multifocally throughout the section, septal capillaries and larger vessels contain and are frequently occluded and distended by many enlarged macrophages distended up to 40 microns by intracytoplasmic, developing schizonts containing many, 1-3 um, basophilic merozoites.  Affected vessels contain mildly hypertrophic endothelial cells within the tunica intima, that have enlarged nuclei; there is multifocal, mild, expansion of the tunica media and adventitia by edema and small amounts of fibrin.  There is prominent perivascular edema with small amounts of hemorrhage.  There are few, partially occlusive fibrin thrombi. Peribronchiolar tissue is mildly expanded by edema.  Multifocally alveolar septa contain a small increase in histiocytes and lymphocytes.  There is mild sub-pleural edema.

MORPHOLOGIC DIAGNOSIS:  Lung:  Vessel occlusion by numerous schizont-laden macrophages(etiology consistent with Cytauxzoon felis) with, acute, multifocal, moderate with perivascular edema, few fibrin thrombi and mild interstitial pneumonia, breed unspecified, feline.

ETIOLOGIC DIAGNOSIS:  Pulmonary cytauxzoonosis

CAUSE: Cytauxzoon felis

GENERAL DISCUSSION:

PATHOGENESIS:

LIFE CYCLE:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES

  1. Aschenbroich SA, Rech RR, Sousa RS, Carmicheal KP, Sakamoto K. Pathology in Practice. J Am Vet Med Assoc. 2012; 240(2): 159-161.
  2. Boes KM, Durham AC. Bone marrow, blood cells and the lymphoid/lymphatic system. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Mosby; 2017:724.
  3. Clarke LL, Rissi DR. Neuropathology of Natural Cytauxzoon felis infection in domestic cats. Vet Pathol. 2015: 52(6): 1167-1171.
  4. Clarke LL, Krimer PM, Rissi DR. Glial changes and evidence for apoptosis in the brain of cats infected by Cytauxzoon felis. J Comp Path. 2017; 156: 147-151.
  5. Valli VEO, Kiupel M, Bienzle D, Wood RD. Hematopoetic system. In: Maxie MG, ed. Jubb, Kennedy, Palmer's Pathology of Domestic Animals. 6th ed. St. Louis, MO. Elsevier; 2016:(3):120.


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