JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

September 2017

P-P18

 

Signalment (JPC #1647279):  An adult rhesus macaque

HISTORY:  Wild-caught rhesus macaque

HISTOPATHOLOGIC DESCRIPTION: Lung: The walls of bronchioles are expanded and occasionally effaced by large numbers of infiltrating neutrophils, macrophages, eosinophils, fewer multinucleated giant cells, lymphocytes, and plasma cells which often extend into the adjacent parenchma. Multifocally bronchiolar epithelium is attenuated, absent, or occasionally hyperplastic, there is fibrosis and smooth muscle hyperplasia within bronchiole walls and peri-bronchiolar lymphoid tissue is hyperplastic. Occasionally there are few cross sections of adult arthropod parasites within the lumen or wall of bronchioles. Arthropods are approximately 300‑500 um in width, and contain a chitinized exoskeleton, jointed appendages, striated musculature, a body cavity, digestive tract, and neural tissue. Multifocally throughout the section there are aggregates of macrophages which contain intracytoplasmic golden-brown to black finely granular birefringent material (mite pigment). There is moderate perivascular fibrosis, smooth muscle hypertrophy, and perivascular edema. Within the surrounding alveoli are increased numbers of alveolar macrophages admixed with eosinophils, lymphocytes, plasma cells, fibrin, hemorrhage, and edema. 

MORPHOLOGIC DIAGNOSIS: Lung: Bronchiolitis and bronchitis, pyogranulomatous and eosinophilic, chronic, multifocal, moderate, with fibrosis, smooth muscle hypertrophy, lymphoid hyperplasia, and bronchiolar and bronchial intraluminal arthropods with mite pigment, etiology consistent with Pneumonyssus simicola, rhesus macaque (Macaca mulatta), non-human primate.

ETIOLOGIC DIAGNOSIS:  Pulmonary pneumonyssiasis

CAUSE:  Pneumonyssus simicola

GENERAL DISCUSSION:

LIFE CYCLE:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS: (gross differential)

COMPARATIVE PATHOLOGY:  Arthropods of the respiratory tract include:

REFERENCES:

  1. Bowman DD. Georgis Parasitology for Veterinarians. 9th ed. St Louis, MO: Saunders Elsevier; 2009:63.
  2. Gardiner CH, Poyton SL. An Atlas of Metazoan Parasites in Animal Tissues. Washington, DC: Armed Forces Institute of Pathology; 1999:56-58.
  3. Lowenstine LJ, Osborn KG. Respiratory system diseases of nonhuman primates. In: Abee C, Mansfield K, Tardif S, Morris T, eds. Nonhuman Primates in Biomedical Research: Diseases. London, UK: Academic Press; 2012:467-468.
  4. Purcell JE, Philipp MT. Parasitic Diseases of Nonhuman Primates: In Wolfe-Coote S, ed. The Laboratory Primate. San Diego, CA: Elsevier; 2005:589-590.
  5. Shirai N, Geoly FJ. Eosinophilic airway inflammation in a Cynomolgus monkey.  Vet Pathol. 2010; 47(2): 318-321.
  6. Strait K, Else JG, Eberhard ML. Parasitic diseases of nonhuman primates. In: Abee CR, Mansfield K, Tardiff S, Morris T, eds. Nonhuman Primates in Biomedical Research: Diseases. 2nd ed. Vol. 2. San Diego, CA: Academic Press; 2012:268-270.

Thornton 2017


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