JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
October 2018
D-P16 (NP)

SIGNALMENT (JPC# 1852297):  Adult wild-caught female Cebus monkey (Cebus sp.)

HISTORY:  Incidental necropsy finding with numerous 0.5 to 2.5 cm diameter grayish-tan nodules on the serosal surface of the duodenum and jejunum

HISTOPATHOLOGIC DESCRIPTION:  Small intestine:  Markedly expanding and compressing the tunica muscularis and elevating the overlying serosa, or within the adjacent mesenteric adipose tissue, are multifocal 4 to 5 mm diameter well demarcated granulomas characterized by a discontinuous fibrous capsule surrounding a rim of numerous epithelioid macrophages, eosinophils, degenerate and viable neutrophils and few lymphocytes and plasma cells, which surrounds multiple cross and tangential sections of adult nematodes and eggs, fibrin, eosinophilic homogenous material and necrotic debris.  Nematodes are up to 120 um in diameter, have a 5 um thick eosinophilic hyaline cuticle with evenly spaced longitudinal cuticular ridges, a pseudocoelom, platymyarian-meromyarian musculature, and a prominent digestive tract lined by few multinucleate cells with a low brush border.  Eggs are 30-50 um in diameter and thin shelled and contain morula or larvae.  Lymphocytes, plasma cells and eosinophils extend into the adjacent serosa, submucosa, and into the lamina propria. The tunica muscularis adjacent to the granulomas is often lost and replaced by fibrous connective tissue. The majority of the intestinal mucosa is autolytic.

MORPHOLOGIC DIAGNOSIS:  Small intestine:  Granulomas, serosal and mesenteric, chronic, multifocal, moderate with multiple adult trichostrongyle nematodes and eggs, etiology consistent with Molineus torulosusand mild lymphoplasmacytic enteritis, Cebus monkey (Cebus sp.), nonhuman primate.

ETIOLOGY:  Molineus torulosus

ETIOLOGIC DIAGNOSIS:  Enteric trichostrongylosis

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

REFERENCES:

  1. Abee CR, Mansfield K, Tardif S, Morris T. Nonhuman Primates in Biomedical Research: Diseases. San Diego, CA: Academic Press; 2012: 233-234.
  2. Brack M, Myers BJ, Kuntz RE. Pathogenic properties of Molineus torulosus in Capuchin monkeys, Cebus apella. Lab Anim Sci. 1973; 23:360-5.
  3. Chitwood M, Lichtenfels JR. Identification of parasitic metazoa in tissue sections. Exp Parasitol. 1972; 32:407-519.
  4. Durette-Desset MC, Fribourg Blanc LA, Vuong PN. Molineus torulosus (Nematoda, Trichostrongylina, Molineoidea) a parasite of neotropical primates: New morphological and histological data. Parasite. 2001; 8(1):53-60.
  5. Miguel MP, Duarte SC, Santos AS. Mortality of Cebus apella by Molineus torulosus parasitism in midwestern Brazil. Acta Scientiae Veterinariae. 2013; 41(1):1-4.
  6. Toft II JD. The pathoparasitology of the alimentary tract and pancreas of nonhuman primates: a review. Vet Pathol. 1982; 19(Suppl. 7):44-92.


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