Musculoskeletal System
April 2019

Signalment (JPC #2548693):  5-year-old male ferret (Mustela putorius furo)

HISTORY:  The ferret presented with a nodule at the tip of the tail.

HISTOPATHOLOGIC DESCRIPTION:  Haired skin and subcutis, tail: Expanding the subcutis, elevating the overlying dermis and epidermis, and compressing adnexa is an unencapsulated, well-circumscribed, multilobulated neoplasm, composed of spindle cells arranged in lobules separated by a fine fibrovascular to mucinous stroma. Neoplastic cells have distinct cell borders and abundant cytoplasm filled by one or more discrete, clear, varisized vacuoles that often displace the nucleus (physaliferous cells). Nuclei are irregularly oval with coarsely clumped chromatin and indistinct nucleoli. At the periphery of the lobules, neoplastic cells are stellate to spindle with scant eosinophilic fibrillar cytoplasm and round to oval nuclei with coarsely or finely stippled chromatin and 1-2 variably distinct nuclei. Mitotic figures average less than 1 per 10 HPF. There is mild anisocytosis and anisokaryosis. Multifocally, neoplastic cells are embedded within a basophilic mucinous matrix and there are scattered islands of cartilage and woven and lamellar trabecular bone lined by rare osteoblasts and few osteoclasts in Howship’s lacunae.  Within the central marrow space, there is loosely arranged spindle cells and few hematopoietic elements. In the adjacent dermis, there are few small aggregates of lymphocytes and plasma cells and few mildly ectatic apocrine glands. There is diffuse mild orthokeratotic hyperkeratosis in the epidermis.

MORPHOLOGIC DIAGNOSIS:  Tail, haired skin and subcutis with bone:  Chordoma, ferret (Mustela putorius furo), mustelid.









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