JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
September 2018
D-M19

Signalment (JPC Accession # 4070541):  9-month-old, intact female Persian cat

HISTORY:  This cat had a history of intermittent vomiting and failure to gain weight.  Abdominal radiographs revealed a mass at the gastric pylorus.  Exploratory laparotomy revealed a thickened gastric pylorus region characterized by a thickened wall and roughened mucosal surface.

HISTOPATHOLOGIC DESCRIPTION:  Stomach, pylorus:  Affecting 90% of this section, the wall of the pylorus is transmurally effaced by a mass-forming proliferation of innumerable large, plump fibroblasts arranged in long, interlacing streams and bundles.  Fibroblasts have large oval nuclei with finely stippled chromatin, prominent nucleoli, and up to 3 mitoses per 10 HPF.  Thick bands of branching and anastomosing fibrous connective tissue with variable maturity from loose and immature to dense and sclerotic are arrayed in a herringbone pattern throughout the mass.  Admixed are large numbers of eosinophils and fewer macrophages and plasma cells.  Within the overlying/adjacent mucosa, gastric glands are decreased in number and often dilated, and the lamina propria is expanded by increased amounts of fibrous connective tissue and slightly increased numbers of lymphocytes, plasma cells, histiocytes, and eosinophils.  The interface between the remaining mucosa and the fibrous mass is composed of a large bed of granulation tissue which blends imperceptibly with the advancing front of the fibrous mass.  At the edges of the fibrous mass, muscle fibers of the muscular tunics are shrunken and hypereosinophilic (atrophy and necrosis), and are surrounded by infiltrating fibrous connective tissue.  Fibrous connective tissue infiltrates and expands perivascular tissue throughout much of the remaining muscular tunics.  There are multiple lymphoid nodules within the serosa, and serosal vessels are often surrounded by edema and moderate numbers of eosinophils and lymphocytes.

MORPHOLOGIC DIAGNOSES:  Stomach:  Gastritis, ulcerative, eosinophilic, and sclerosing, transmural, focally extensive, marked, Persian, feline.

CAUSE:  Idiopathic

CONDITION:  Feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF); scirrhous eosinophilic gastritis

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

References:

  1. Brosinski K, Burkhardt WA, Venzin C, Grest P. Diagnostic exercise: submucosal gastric masses in a cat.  Pathol. 2013;50(2):350-353.
  2. Craig LE, Hardam EE, Hertzke DM, et al. Feline Gastrointestinal eosinophilic sclerosing fibroplasia. Vet Pathol. 2009;46(1):63-70.
  3. Eckstrand CD, Barr BC, Woods LW, Spangler T, Murphy B. Nematode-associated intramural alimentary nodules in pumas are histologically similar to gastrointestinal eosinophilic sclerosing fibroplasia of domestic cats.  Pathol.  2013;148:405-409.
  4. Gelberg HB. Alimentary system and the peritoneum, omentum, mesentery, and peritoneal vacity. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:362-363.
  5. Grau-Roma L, Galindo-Cardiel I, Isidoro-Ayza M, Fernandez M, Majo N. A case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with phycomycetes.  Pathol.  2014;151:318-321.
  6. Uzal FA, Plattner BL, Hostetter JM. Alimentary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:96.


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