JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
December 2017
U-B04

SIGNALMENT (JPC # 1549986): German shepherd dog

HISTORY: Tissue from a German shepherd military working dog which had several episodes of epistaxis and seemed lethargic

HISTOPATHOLOGIC DESCRIPTION: Kidney: Multifocally expanding the renal interstitium at the corticomedullary junction and radiating into the medulla and cortex are numerous plasma cells admixed with fewer lymphocytes and macrophages that surround small vessels and that widely separate tubules.  Multifocally within the medulla, away from the corticomedullary junction, there are similar plasma cell rich infiltrates surrounding vessels, tubules and glomeruli.  Multifocally within affected areas, tubules are either ectatic and lined by attenuated epithelium, or are lined by tubular epithelial cells that have lost cellular detail with few clear intracytoplasmic vacuoles (degeneration) or are necrotic characterized by occasional condensed pyknotic nuclei or occasionally sloughed into tubular lumina. Occasionally tubules contain pale homogenous eosinophilic fluid (tubular proteinosis). Few glomeruli have mild periglomerular fibrosis. Multifocally, tubular epithelium in adjacent less affected areas contains a golden brown intracytoplasmic pigment (hemosiderin and/or lipofuscin).

MORPHOLOGIC DIAGNOSIS: Kidney: Nephritis, interstitial and perivascular, plasmacytic, chronic, multifocal, moderate, with minimal tubular necrosis, atrophy, and degeneration, German shepherd dog, canine.

ETIOLOGIC DIAGNOSIS: Renal ehrlichiosis

CAUSE: Ehrlichia canis

CONDITION: Tropical canine pancytopenia, canine hemorrhagic fever, monocytic ehrlichiosis

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL SIGNS:

TYPICAL CLINICAL PATHOLOGY FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC DIAGNOSIS:

DIFFERENTIAL DIAGNOSIS:

Other Canine Rickettsial Organisms:

Other Immune-Mediated Disorders:

Other causes of thrombocytopenia, anemia or prolonged bleeding time:

Miscellaneous: Acute canine polyradiculoneuritis (model for the acute axonal form of Guillain-Barre syndrome): serologic evidence rules out E. canis as the cause and serologically is linked to Toxoplasma gondii as the cause

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Boes KM, Durham AC. Bone marrow, blood cells, and the lymphoid/lymphatic system. In: McGavin MD, Zachary JF, eds. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Mosby/Elsevier Inc; 2017:749-751.
  2. Cianciolo RE, Mohr FC. Urinary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier Limited; 2016:414, 418.
  3. Holt N, Murray M, Cuddon PA, Lappin MR. Seroprevalence of various infectious agents in dogs with suspected acute canine polyradiculoneuritis. J Vet Intern Med. 2011; 25(2):261-6.
  4. Little SE. Ehrlichiosis and anaplasmosis in dogs and cats. Vet Clin North Am Small Anim Pract. 2010; 40(6):1121-40.
  5. Mylonakis ME, Borjesson DL, Leontides L, et al. Cytologic patterns of lymphadenopathy in canine monocytic ehrlichiosis. Vet Clin Pathol. 2011; 40(1):78-83.
  6. Robinson WF, Robinson NA. Cardiovascular system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier Limited; 2016:80-81.
  7. Valli VEO, Kiupel M, Bienzle D. Hematopoietic system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier Limited; 2016:111, 260.

 

 


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