JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
November 2018
D-V20

Signalment (JPC #1366804):  Chicken

HISTORY:  Sick chicken that died.

HISTOPATHOLOGIC DESCRIPTION:  Liver:  Affecting approximately 80% of the section are random areas of lytic necrosis characterized by dissociation of hepatic cord architecture with loss of hepatocytes and replacement by eosinophilic cellular and karyorrhectic debris (necrosis), fibrin and hemorrhage. Areas of lytic necrosis are surrounded by either individual necrotic hepatocytes with hypereosinophilic cytoplasm and pyknotic nuclei or degenerate hepatocytes with pale cytoplasm and cytoplasmic vacuolation.  Frequently, degenerate hepatocytes contain round, amphophilic to basophilic smudgy intranuclear inclusion bodies that fill and expand the nucleus up to 20 um in diameter.  Multifocally portal areas are expanded by moderate numbers of heterophils, lymphocytes, fewer macrophages, and plasma cells.

MORPHOLOGIC DIAGNOSIS:  Liver: Hepatitis, necrotizing, random, acute, with basophilic intranuclear viral inclusion bodies, chicken, avian.

ETIOLOGIC DIAGNOSIS:  Adenoviral hepatitis

CAUSE:   Fowl adenovirus

CONDITION:  Inclusion body hepatitis (IBH); hemopericardium syndrome

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL GROSS FINDINGS:

TYPICAL MICROSCOPIC FINDINGS:

ULTRASTRUCTURE:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

Avian Adenoviruses:

Mammalian Adenoviruses (mastadenovirus):

REFERENCES:

  1. Fitzgerald SD. Adenovirus infections. In: Swayne DE et al, eds. Diseases of Poultry. 13th ed., Ames, IA: John Wiley & Sons, Inc.; 2013:289-320.
  2. Himmel L, O’Connor M, Premanandan C. Necrotizing hepatitis in a domestic pigeon (Columbia livia). Vet Pathol. 2014:51(6):1171-1173.
  3. Abdul-Aziz T, Barnes HJ. Gross Pathology of Avian Diseases:  Text and Atlas.  Jacksonville, FL:  American Association of Avian Pathologists, Inc.; 2018:87-88. 
  4. Ojkic D, Brash ML, Jackwood MW, Shivaprasad HL. Viral Diseases.  In: Boulianne M et al, eds. Avian Disease Manual. 7th, Jacksonville, FL: American Association of Avian Pathologists, Inc.; 2013:10-17,251.
  5. Wachtman L, Mansfield K. Viral diseases of nonhuman primates. In: Abee CR, Mansfield K, Tardif S, Morris T, Morris T, eds.  Nonhuman Primates in Biomedical Research.  London, UK: Academic Press; 2012: 27-30.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |