JPC SYSTEMIC PATHOLOGY
ENDOCRINE SYSTEM
January 2019
E-N01

Signalment (JPC#1946890):  9-year-old male English springer spaniel

HISTORY:  This dog had chronic pyoderma, alopecia, polyuria, polydipsia, rapid weight loss, and calcinosis cutis. 

HISTOPATHOLOGIC DESCRIPTION:  Pituitary gland, pars distalis:  Expanding and replacing the normal pituitary architecture and compressing the adjacent remaining rim of normal pars distalis is an 8 x 7mm, unencapsulated, well circumscribed neoplasm composed of polygonal cells arranged in nests, packets, and trabeculae supported by a fine fibrovascular stroma and separated by variably sized sinusoidal spaces.  Neoplastic cells have indistinct cell borders, moderate amounts of microvacuolated to granular eosinophilic cytoplasm, a round nucleus with an antibasilar orientation and vesiculate chromatin with one generally distinct nucleolus.  Mitoses average less than 1 per 10 HPF, and there is mild anisocytosis and anisokaryosis.  Focally compressing a thin rim of remaining pars distalis is an 8 mm diameter cyst lined by attenuated to cuboidal, often ciliated epithelium and containing hemorrhage, fibrin, acicular clefts (cholesterol), basophilic granular material (mineral), hematoidin, hemosiderin-laden macrophages and moderate amounts of fibrous connective tissue.

MORPHOLOGIC DIAGNOSES: 

  1. Pituitary gland, pars distalis:  Adenoma, English springer spaniel, canine.
  2. Pituitary gland: Cyst, craniopharyngeal duct origin. 

GENERAL: 

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL MICROSCOPIC FINDINGS: 

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS: 

For gross pituitary mass:

For histologic findings:

COMPARATIVE PATHOLOGY: 

REFERENCES: 

  1. Bakthavatchalu V, Muthupalani S, Marini RS, Fox JG. Endocrinopathy and aging in ferrets.Vet Pathol. 2016; 53(2):349-65.
  2. Rosol TJ, Meuten DJ. Tumors of the endocrine glands. In: Meuten DJ, ed. Tumors in Domestic Animals. 5th ed. Ames, IA: John Wiley & Sons, Inc; 2017:768-782.
  3. Chalkley MD, Kiupel M, Draper ACE. Pituitary null cell adenoma in a domestic llama (Lama glama) J Comp Pathol. 2014; 151(1):51-56.
  4. Gilsenan WF, Habecker PL, Coyne TM, Johnson AL. Neurologic disease attributed to a pituitary adenoma in an alpaca. J Vet Intern Med. 2012;26(4):1073-1077.
  5. Langohr IM, Garner MM, Kiupel M. Somatotroph pituitary tumors in budgerigars (Melopsittacus undulates). Vet Pathol. 2012;49(3):503-506.
  6. Miller MA. Endocrine system. In: McGavin MD, Zachary JF, eds. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier, Inc; 2017:681-685.
  7. Miller MA, Bruyette DS, Scott-Moncrieff JC, Owen TJ, Ramos-Vara JA, Weng HY, Vanderpool AL, Chen AV, Martin LG, DuSold DM, Jahan S. Histopathologic Findings in Canine Pituitary Glands. Vet Pathol. 2018;55(6):871-879.
  8. Miller MA, Owen TJ, Bruyette DS, Scott-Moncrieff JC, Ramos-Vara JA, Weng HY, Chen AV, Martin LG, DuSold DM. Immunohistochemical Evaluation of Canine Pituitary Adenomas Obtained by Transsphenoidal Hypophysectomy. Vet Pathol. 2018;55(6):889-895.
  9. Percy DH, Barthold SW. Pathology of Laboratory Rodents & Rabbits. 4th ed. Ames, IA: John Wiley & Sons, Inc; 2016:116-117, 168-169, 313.
  10. Polledo L, Grinwis GCM, Graham P, Dunning M, Baiker K. Pathological Findings in the Pituitary Glands of Dogs and Cats. Vet Pathol. 2018;55(6):880-888.
  11. Rosol T, Grone A. Endocrine glands. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St Louis, MO: Elsevier Saunders; 2016:276-289.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |