JPC SYSTEMIC PATHOLOGY
REPRODUCTIVE SYSTEM
January 2019
R-B07

Signalment (JPC #1758839):  African pygmy goat

HISTORY:  Multiple near term abortions occurred in a research herd of African pygmy goats.  Placentas were covered with tan mucoid exudates, cotyledons were hemorrhagic, and necrotic villi were noted.  Cultures of fetal stomach contents were negative for bacterial growth.

HISTOPATHOLOGIC DESCRIPTION:  Slide A:  Chorioallantois:  Diffusely, there is effacement of the chorioallantoic villar architecture with degeneration, necrosis and loss of the chorionic epithelium andreplacement by abundant necrotic debris, mineral, hemorrhage (lytic necrosis) and scattered sloughed cytotrophoblast and syncytiotrophoblast cells, admixed with numerous degenerate neutrophils, with fewer macrophages, lymphocytes and plasma cells.  Multifocally abundant necrotic debris, degenerate neutrophils, fibrin, hemorrhage and edema expand the space between villi. Multifocally, there are numerous 1.0 um pleomorphic coccoid to rod-shaped organisms expanding the cytoplasm of trophoblasts, and less commonly, macrophages.   The chorioallantoic stroma is multifocally expanded by eosinophilic or basophilic, finely granular material (mineral), clear space and ectatic lymphatics (edema), and moderate numbers of lymphocytes, plasma cells and fewer macrophages.  Multifocally within the intercotyledonary chorion the surface is ulcerated with loss of the epithelium and replacement by degenerate neutrophils, fibrin, hemorrhage and necrotic debris, or the remaining epithelium is hypertrophic and hyperplastic with the cytoplasm being distended by abundant 1um basophilic pleomorphic coccid bacteria.

Slide B, Giemsa:  Intratrophoblastic coccobacilli stain purple to magenta.

MORPHOLOGIC DIAGNOSIS:  Chorioallantois:  Placentitis, necrotizing and suppurative, subacute, diffuse, severe, with numerous intratrophoblastic and intrahistiocytic coccobacilli, African pygmy goat, caprine.

ETIOLOGIC DIAGNOSIS:  Coxiella placentitis

CAUSE:  Coxiella burnetii

CONDITION:  Q Fever (“Query fever”) in man

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

Abortions in sheep:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. De Biase, Costagliola A, Del Piero F, et al. Coxiella burnetii in infertile dairy cattle with chronic endometritis. Vet Pathol. 2018; 55(4):539-542.
  2. Emery MP, Ostlund EN, Schmitt BJ. Comparison of Q fever serology methods in cattle, goats and sheep. J Vet Diagn Invest. 2012; 24(2):379-382.
  3. Foster RA. Female reproductive system and mammae. In: McGavin MD, Zachary JF, eds. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:1183.
  4. Garcia-Seco T, Perez-Sancho M, Martinez-Nevado E, et al. Detection of Coxiella burnetii in a Saharawi dorcas gazelle (Gazella dorcas neglecta). J Zoo Wildlife Med. 2016; 47(1):939-941.
  5. Greene CE. Francisella and Coxiella In: Greene CE, ed. Infectious Diseases of the Dog and Cat. 4th ed. St. Louis, MO: Elsevier Saunders; 2012:482-484.
  6. Kelly PJ. Q fever. In: Coetzer JAW, Tustin RC, eds. Infectious Diseases of Livestock. Vol 1. 2nd ed. Oxford, UK: Oxford University Press; 2004:565-572.
  7. Schlafer DH, Foster RA. Female genital system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier; 2016:416-7.
  8. Myers E, Ehrhart EJ, Charles B, Spraker T, Gelatt T and Duncan C. Apoptosis in normal and Coxiella burnetii-infected placentas from Alaskan northern fur seals (Callorhinus ursinus). Vet Pathol. 2013; 50(4):622-625.
  9. Vapniarsky N, Barr BC, Murphy B. Systemic Coxiella-like infection with myocarditis and hepatitis in an Eclectus parrot (Eclectus roratus). Vet Pathol. 2012; 49(4):717-724.
  10. Gonzalez-Barrio D, Maio E, Vieira-Pinto M, Ruiz-Fons F. European rabbits as reservoir for Coxiella burnetii. Emerg Infect Dis. 2015; 21(6):1055-1058.


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