JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
January 2018
U-M24

SIGNALMENT (AFIP # 2194476):  A dog.

HISTORY:  This dog had persistent urinary tract infections.  Contrast radiography revealed irregularities in the mucosal surface of the urinary bladder.

HISTOPATHOLOGIC DESCRIPTION: Urinary bladder (2 sections): Expanding the lamina propria and elevating the overlying hyperplastic transitional epithelium are multiple polypoid masses composed of a core of loosely arranged fibrovascular tissue that contains numerous small caliber vessels and moderate numbers of neutrophils, lymphocytes, plasma cells, fewer macrophages, moderate edema, congestion, and hemorrhage.  There are moderate numbers of neutrophils within the epithelium that occasionally form intraepithelial microabscesses.  Scattered epithelial cells are swollen and have clear cytoplasm (hydropic degeneration), and there are areas of epithelial attenuation and ulceration.  The superficial lamina propria often contains high numbers of closely packed viable and degenerate inflammatory cells.  Multifocally, the ulcerated epithelium is covered by a thin layer of fibrin, serum, and necrotic cells (serocellular crust).

MORPHOLOGIC DIAGNOSIS: Urinary bladder: Cystitis, polypoid and chronic-active, multifocal, moderate, with multifocal erosion and ulceration, hemorrhage and edema, breed not specified, canine.

CONDITION: Chronic polypoid cystitis

GENERAL DISCUSSION: 

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

DIFFERENTIAL DIAGNOSIS: 

Gross and histologic

COMPARATIVE PATHOLOGY: 

REFERENCES: 

  1. Breshears MA, Confer AW. The urinary system. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Mosby; 2017:669-670.
  2. Cianciolo RE, Mohr FC. Urinary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier; 2016:460-461.
  3. Girolamo ND, Bongiovanni L, Ferro S et al. Cystoscopic diagnosis of polypoid cystitis in two pet rabbits. J Am Vet Med Assoc. 2017; 251(1): 84-89.
  4. Sledge DG, Patrick DJ, Fitzgerald SD et al. Differences in expression of uroplakin III, cytokeratin 7, and cyclooxygenase-2 in canine proliferative urothelial lesions of the urinary bladder. Vet Pathol. 2015; 52(1): 74-82.

 

 

 

 


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