JPC SYSTEMIC PATHOLOGY
REPRODUCTIVE SYSTEM
January 2019
R-M02 (NP)

Signalment (JPC #2118235):  Female chinchilla

HISTORY:  None.

HISTOPATHOLOGIC DESCRIPTION:  Lung:  Multifocally, alveolar capillary lumens are occluded by small aggregates of irregularly round, uninucleate or binucleate placental trophoblasts which measure up to 150 um in diameter.  Trophoblasts have an abundant amount of amphophilic, finely granular to microvacuolated cytoplasm and one round to oval, 30-50 um diameter nuclei with clumped chromatin.  Diffusely, alveolar septa are mildly expanded by dilated capillaries, edema, fibrin, low numbers of lymphocytes and fewer neutrophils.  Multifocally, alveolar lumina contain an increased number of alveolar macrophages and a minimal amount of fibrin. 

Uterus:  Essentially normal tissue.

MORPHOLOGIC DIAGNOSIS:  Lung, alveolar capillaries:  Trophoblast emboli, multifocal, mild, chinchilla (Chinchilla lanigera), rodent.

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Burek JD, Goldberg B, Hutchins G, Strandberg JD. The pregnant Syrian hamster as a model to study intravascular trophoblasts and associated maternal blood vessel changes. Vet Pathol. 1979;16(5):556‑566.
  2. Chen Q, Stone P, Ching LM, Chamley L. A role for interleukin-6 in spreading endothelial cell activation after phagocytosis of necrotic trophoblastic material: implications for the pathogenesis of pre-eclampsia. J Pathol. 2009;217(1):122-130.
  3. Kliman HJ. Uteroplacental blood flow. The story of decidualization, menstruation and trophoblast invasion. Am J Pathol. 2000;157(6):1759-1768.
  4. La Perle KMD, Green MG, Niewiesk S. Trophoblast Deportation to the Lungs of Cotton Rats (Sigmoden hispidus). Comp Med. 2014;64(6):448-455.
  5. Noden DM, De Lahanta A. The Embryology of Domestic Animals: Developmental Mechanisms and Malformations. Baltimore, MD:Williams and Wilkins;1985:50‑69.
  6. Tvedten HW, Langham RF. Trophoblastic emboli in a chinchilla. J Am Vet Med Assoc. 1974;165(9):828‑829.


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