JPC SYSTEMIC PATHOLOGY
ENDOCRINE SYSTEM
February 2019
E-N08 (NP)

SIGNALMENT (JPC # 1903951):  10-year-old German shepherd dog

HISTORY:  Incidental finding

HISTOPATHOLOGIC DESCRIPTION:  Adrenal gland:  Multifocally, expanding the subcapsular, intracapsular, and extracapsular cortical regions, there are unencapsulated nodules of polygonal cells arranged in nests and packets that resemble normal cells of the zona glomerulosa and zona reticularis.  Nodules vary from 50um to 1mm in diameter and are separated into nests and packets by a fine fibrovascular stroma.  In the largest extracapsular nodule there are small aggregates of basophilic granular material (mineral).  There are multifocal nests of cells in the zona fasciculata and reticularis with abundant microvacuolated clear to yellow cytoplasm which peripheralizes the nucleus (lipoidal degeneration).

MORPHOLOGIC DIAGNOSIS:  Adrenal gland:  Hyperplasia, cortical, nodular, multifocal, mild, German shepherd dog, canine.

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

attached to and prolapsing through the capsule

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:  

For gross finding of adrenal enlargement and/or adrenal gland nodules (note:  Nodular hyperplasia may occur concurrently):

COMPARATIVE PATHOLOGY:

References:

  1. Miller MA, Bruyette DS, Scott-Moncrieff JC, et al. Histopathologic Findings in Canine Pituitary Glands. Vet Pathol. 2018; 55(6):871-879.
  2. Miller MA. Endocrine system. In: Zachary JF, eds. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier, Inc; 2017:707-709.
  3. Rosol TJ, Gröne, A. Endocrine glands. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed, St. Louis, MO: Elsevier; 2016: 343-345.
  4. Rosol TJ, Meuten DJ. Tumors of the endocrine glands. In: Meuten DJ, ed. Tumors in Domestic Animals.  5th ed. Ames, IA: John Wiley & Sons, Inc; 2017: 782-778.


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