JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
December 2017
U-M04 (NP)

Signalment (JPC 1419010):  A dog.

HISTORY:  Tissue from a diabetic dog.

HISTOPATHOLOGIC DESCRIPTION:  Urinary bladder:  The urinary bladder wall is expanded to 1 cm.  Diffusely expanding the submucosa and multifocally widely separating and compressing the connective tissue and muscle fibers of the tunica muscularis are round to polygonal clear spaces that lack an epithelial lining (pseudocysts) and are up to 1mm in diameter (emphysema).  Multifocally, the submucosa is moderately expanded by fibrous connective tissue, and myocytes of the tunica muscularis often contain  small intrasarcoplasmic clear vacuoles (degeneration).  The urothelium is hyperplastic and piled up to 20 cell layers deep, and epithelial cells multifocally have vacuolated cytoplasm (hydropic degeneration) and pyknotic nuclei.  The superficial submucosa is multifocally expanded by aggregates of few lymphocytes, plasma cells, macrophages, fewer neutrophils, mild hemorrhage and few hemosiderin-laden macrophages.  Lymphatics in the superficial submucosa are often ectatic and surrounded by clear space (edema). 

MORPHOLOGIC DIAGNOSIS:  Urinary bladder, submucosa and muscularis mucosa:  Emphysema, diffuse, moderate, with multifocal mild lymphoplasmacytic cystitis, transmural edema, and moderate urothelial hyperplasia, breed unspecified, canine.

ETIOLOGIC DIAGNOSIS:  Bacterial emphysematous cystitis

CAUSE:  Glucose-fermenting bacteria or yeast

CONDITION:  Emphysematous cystitis

GENERAL DISCUSSION: 

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY: 

REFERENCES:   

  1. Almondia DY, Williams J. What is your diagnosis? Emphysematous cystitis. J Am Vet Med Assoc. 2010;237(2):159-60.
  2. Breshears MA, Confer AW. The urinary system. In: McGavin MD, Zachary JF, eds. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier;2016:653-654.
  3. Cianciolo RE, Mohr FC.. Urinary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer"s Pathology of Domestic Animals. 6th ed. Vol 2. Philadelphia, PA: Elsevier Saunders;2016:459-460.
  4. Cohn LA, Cook CR, Priddy N, Johannes C. What is your diagnosis? Emphysematous cystitis, pneumaturia and lumbar spondylosis. J Am Vet Med Assoc. 2001;218(5):703-4.
  5. Lobetti RG, Goldin JP: Emphysematous cystitis and bladder trigone diverticulum in a dog. J Small Anim Pract. 1998;39(3):144-7.
  6. Merkel LK, Lulich J, Polzin D, Ober C, Westropp J, Sykes J. Clinicopathologic and microbiologic findings associated with emphysematous cystitis in 27 dogs. J Am Anim Hosp Assoc. 2017 Nov/Dec;53(6):313-320. doi: 10.5326/JAAHA-MS-6722. Epub 2017 Sep 11.
  7. Newman SJ, Confer AW, Panciera RJ: Urinary system. In: Pathologic Basis of Veterinary Disease, eds. McGavin MD, Zachary JF, 4th ed., p. 628. Mosby Elsevier, St. Louis, MO, 2007

 

 

 


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |