JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
October 2018
D-P12 (NP)

Signalment (JPC #1699088):  A chimpanzee (Pan troglodytes)

HISTORY:  This animal lived for many years in a large southwestern zoo and died from disseminated tuberculosis.  This was an incidental finding.

HISTOPATHOLOGIC DESCRIPTION:  Colon: Circumferentially, there is mucosal erosion and an overall decrease in the number of colonic crypts.  The remaining crypts are surrounded and separated by variably sized, infiltrating aggregates of lymphocytes, plasma cells, and eosinophils that extend into and along with edema, expand the lamina propria.  These inflammatory cells also multifocally surround submucosal vessels.  Several submucosal arteries are lined by hypertrophied endothelial cells, with occasionally transmigrating eosinophils within the tunica media.  Within the colonic lumen, there are few cross and tangential sections of a 90-150 um diameter nematode with a 5 um thin cuticle with lateral alae, platymyarian-meromyarian musculature, a pseudocoelom, and a muscular esophagus with a triradiate lumen.

Small intestine:  Multifocally many eosinophils, lymphocytes and plasma cells expand the lamina propria and submucosa.  Admixed with enterocytes are increased numbers of goblet cells (hyperplasia).  Embedded at various depths within the mucosa and within the lumen are longitudinal and cross-sections of nematodes as described above.

MORPHOLOGIC DIAGNOSIS:  Colon; small intestine:  Colitis and enteritis, lymphoplasmacytic and eosinophilic, circumferential, moderate, with goblet cell hyperplasia and few Oxyurid nematodes, etiology consistent with Enterobius sp., chimpanzee (Pan troglodytes), nonhuman primate.

CAUSE:  Enterobius sp.

ETIOLOGIC DIAGNOSIS:  Intestinal enterobiasis

CONDITION:  Pinworm infection

GENERAL DISCUSSION:

LIFE CYCLE:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, Iowa: Blackwell Publishing; 2016: 84-85,152,190,205,301.
  2. Gardiner CH, Poynton SL. An Atlas of Metazoan Parasites in Animal Tissues. Washington, D.C: Armed Institute of Pathology; 2006:5,17-18.
  3. Gelberg HB. Alimentary system and the peritoneum, omentum, mesentery, and peritoneal cavity. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:385.
  4. Radostits OM, Gray CC, Hinchcliff KW, Constable PD. Veterinary Medicine. 10th ed. Philadelphia, PA: Saunders Elselvier: 2007:1562.
  5. Jones TC, Hunt RC, King NW. Veterinary Pathology. 6th ed. Baltimore, MD: Williams & Wilkins; 1997:640-641.
  6. Strait K, Else JG, Eberhard ML. Parasitic diseases of nonhuman primates. In: Abee CR, Mansfield K, Tardiff S, Morris T, eds. Nonhuman Primates in Biomedical Research. 2. 2nd ed. San Diego, CA: Elselvier; 2012:231.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |