JPC SYSTEMIC PATHOLOGY

INTEGUMENT SYSTEM

November 2016

I-V02 (NP)

 

Signalment (JPC #1818935):  White-tailed deer (Odocoileus virginianus

HISTORY:  Proliferative dermal mass

HISTOPATHOLOGIC DESCRIPTION:  Haired skin:  Expanding the dermis, elevating the overlying mildly hyperplastic epidermis and extending to cut borders is a moderately cellular neoplasm composed of spindle cells arranged in long interlacing streams and bundles on a moderate collagenous matrix.  Neoplastic cells have indistinct cell borders, scant amount of pale eosinophilic, fibrillar cytoplasm, one oval to fusiform, vesiculate nucleus with finely stippled chromatin, and one variably distinct nucleolus.   There is mild anisocytosis and anisokaryosis.  The mitotic rate is 1 per 10 hpf.  There is mild epidermal acanthosis with rete ridge formation and orthokeratosis.  There are multiple macrophages which contain intracytoplasmic melanin (pigmentary incontinence) in the superficial dermis.

MORPHOLOGIC DIAGNOSIS:  Haired skin:  Fibropapilloma, White-tailed deer (Odocoileus virginianus), cervid.

ETIOLOGY:  Deer papillomavirus (DPV)

ETIOLOGIC DIAGNOSIS:  Cutaneous cervid papillomaviral fibropapillomatosis

GENERAL DISCUSION

 PATHOGENESIS:

 TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS

 

TYPICAL LIGHT MICROSCOPIC FINDINGS

ULTRASTRUCTURE:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Cheville NF, Lehmkuhl, H. Cytopathology of viral diseases. In: Cheville, NF, ed. Ultrastructural Pathology: The Comparative Cellular Basis of Disease. 2nd ed. Danvers, MA: Wiley-Blackwell; 2009:343-347.
  2. Cosgrove GE, Satterfield LC, Nettles VF. Neoplasia. In: Davidson, WR, ed. Diseases and Parasites of White‑tailed Deer. 1st ed. Athens, GA: University of GA Press; 1981:62-71.
  3. Erdélyi K, Dencső L, Lehoczki R, et. al. Endemic papillomavirus infection of roe deer (Capreolus capreolus). Vet Microbiol. 2009;138(1-2):20-26.
  4. Mauldin EA, Peters-Kennedy J. Integumentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. St. Louis, MO: Saunders Elsevier; 2016: 706-707.
  5. Sundberg JP, van Ranst M, Jenson AB. Papillomavirus infections. In: Williams ES, Barker IK, eds. Infectious Diseases of Wild Mammals. 3rd ed. Ames, IA: Iowa State University Press; 2001:223-231.
  6. Teifke JP, Kidney BA, Löhr CV, et. al. Detection of papillomavirus-DNA in mesenchymal tumour cells and not in the hyperplastic epithelium of feline sarcoids. Vet Dermatol. 2003;14(1):47-56.
  7. von Bomhard W, Goldschmidt MH, Shofer FS, et. al. Cutaneous neoplasms in pet rabbits: A retrospective study. Vet Pathol. 2007;44(5):579-588.


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