JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

October 2017

P-V14 (NP)

 

Signalment (JPC# 2286754):  4-month-old female mink

HISTORY:  Four mink with history of dyspnea and a mild serous nasal discharge were submitted from a mink farm that was experiencing losses in the current kit crop.

HISTOPATHOLOGIC DESCRIPTION:  Lung:  The section of lung is diffusely consolidated. Alveolar septa are expanded up to 10 times normal by macrophages, fewer lymphocytes and plasma cells, as well as interstitial edema and variable amounts of necrotic cellular debris.  Alveoli are often lined by plump, cuboidal epithelium (type II pneumocyte hyperplasia) which rarely contain variably sized (up to 12um diameter), homogenous, indistinct, amphophilic intranuclear viral inclusion bodies.  Alveolar lumina are variably filled with foamy alveolar macrophages, eosinophilic fibrillar material (fibrin), and sloughed necrotic debris.  Diffusely, perivascular, peribronchiolar, and subpleural connective tissue is expanded by moderate numbers of plasma cells and lymphocytes with edema and dilated lymphatics.  Bronchioles and bronchi contain variable amounts of fibrin with few macrophages, plasma cells and lymphocytes.  The pleura is multifocally mildly thickened up to twice normal by fibrous connective tissue.

MORPHOLOGIC DIAGNOSIS:  Lung:  Pneumonia, interstitial, necrotizing, histiocytic,  diffuse, marked, with type II pneumocyte hyperplasia, peribronchial and perivascular lymphoplasmacytic infiltrates, and rare amphophilic viral intranuclear inclusion bodies, mink (Mustela vision), mustelid.

ETIOLOGIC DIAGNOSIS:  Parvoviral pneumonia

CAUSE:  Aleutian mink disease virus (ADV, AMDV)

GENERAL DISCUSSION: 

 PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ULTRASTRUCTURAL FINDINGS: 

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS: 

Interstitial pneumonia:

Parvovirus:

COMPARATIVE PATHOLOGY: 

ADV in other species:

Other parvoviruses:

Parvovirus in many species targets crypt epithelium of the small intestine, resulting in intestinal disease.  Rodent parvoviruses do not target intestinal epithelium.

 References:   

  1. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, IA: Blackwell Publishing; 2016: 17-19, 122-124, 175-176, 196, 259
  2. Farid AH, Hussain I, Arju I. Detection of Aleutian mink disease virus DNA and antiviral antibodies in American mink (Neovison vison) 10 days postinoculation.  Vet. Diagn. Invest. 2015:27(3):287-294.
  3. Kollias GV, Fernandez-Moran J.   In: Miller RE, Fowler ME.  Fowler’s zoo and wild animal medicine. Vol. 8.  St. Louis, MO: Elsevier; 2015: 484.
  4. Kiupel M, Perpinan D. Viral diseases of ferrets.  In: Fox JG, Marini RP. Biology and diseases of the ferret.  3rd ed.  Ames, IA: Wiley; 2014: 461-467.
  5. LaDouceur EE, Anderson M, Ritchie BW, Ciembor P, Rimoldi G, Piazza M, Pesti D, Clifford DL, Gianniti F. Aleutian disease: an emerging disease in free-ranging striped skunks (Mephitis mephitis) from California.  Pathol. 2015;52(6):1250-1253.
  6. Li L, Pesavento PA, Woods L, et al. Novel amdovirus in gray foxes. Emerg Infect Dis. 2011:17(10):1876-8.
  7. MacLachlan NJ, Dubovi EJ, Eds. Fenner’s Veterinary Virology. 5th ed. San Diego, CA: Academic Press.  2017;245-257.
  8. Nituch LA, Bowman J, Wilson PJ, Schulte-Hostedde AI. Aleutian mink disease virus in striped skunks (Mephitis mephitis): evidence for cross-species spillover.  Wildl. Dis.2015;51(2):389-400.
  9. Quesenberry KE, Carpenter JW. Ferrets, Rabbits, and Rodents Clinical Medicine and Surgery. 3rd ed. St. Louis, MO: Elsevier; 2012: 48, 71-73, 135-136.
  10. Snyder PW. Diseases of immunity. In: Zachary JD, ed., Pathologic Basis of Veterinary Disease.6th ed. St. Louis, MO: Elsevier; 2017: 266.
  11. Uzal FA, Plattner BL, Hostetter JM. Alimentary system.  In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals.  Vol 2. 6th ed. St. Louis, MO: Elsevier; 2016:153-158.
  12. Wilson DJ, Baldwin TJ, Whitehouse CH, Hullinger G. Causes of mortality in farmed mink in the intermountain west, North America.  Vet. Diagn. Invest. 2015:27(4):470-475.


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