October 2017

P-V14 (NP)


Signalment (JPC# 2286754):  4-month-old female mink

HISTORY:  Four mink with history of dyspnea and a mild serous nasal discharge were submitted from a mink farm that was experiencing losses in the current kit crop.

HISTOPATHOLOGIC DESCRIPTION:  Lung:  The section of lung is diffusely consolidated. Alveolar septa are expanded up to 10 times normal by macrophages, fewer lymphocytes and plasma cells, as well as interstitial edema and variable amounts of necrotic cellular debris.  Alveoli are often lined by plump, cuboidal epithelium (type II pneumocyte hyperplasia) which rarely contain variably sized (up to 12um diameter), homogenous, indistinct, amphophilic intranuclear viral inclusion bodies.  Alveolar lumina are variably filled with foamy alveolar macrophages, eosinophilic fibrillar material (fibrin), and sloughed necrotic debris.  Diffusely, perivascular, peribronchiolar, and subpleural connective tissue is expanded by moderate numbers of plasma cells and lymphocytes with edema and dilated lymphatics.  Bronchioles and bronchi contain variable amounts of fibrin with few macrophages, plasma cells and lymphocytes.  The pleura is multifocally mildly thickened up to twice normal by fibrous connective tissue.

MORPHOLOGIC DIAGNOSIS:  Lung:  Pneumonia, interstitial, necrotizing, histiocytic,  diffuse, marked, with type II pneumocyte hyperplasia, peribronchial and perivascular lymphoplasmacytic infiltrates, and rare amphophilic viral intranuclear inclusion bodies, mink (Mustela vision), mustelid.

ETIOLOGIC DIAGNOSIS:  Parvoviral pneumonia

CAUSE:  Aleutian mink disease virus (ADV, AMDV)









Interstitial pneumonia:



ADV in other species:

Other parvoviruses:

Parvovirus in many species targets crypt epithelium of the small intestine, resulting in intestinal disease.  Rodent parvoviruses do not target intestinal epithelium.


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