JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

August 2017

P-B14

 

Signalment (JPC# 1713947):  Bovine neonate

HISTORY:  Tissue from a bovine neonate that was born premature between 220 to 235 days of gestation; it was weak and experienced respiratory difficulty and died shortly after birth.  Its lungs failed to collapse and were uniformly firmer than normal.  All lymph nodes examined were 2‑2.5x normal size. 

HISTOPATHOLOGIC DESCRIPTION:  Lung:  Multifocally obscuring 30% of the pulmonary architecture, expanding and occasionally obliterating alveolar lumina and septa are numerous macrophages, moderate numbers of lymphocytes and plasma cells, few neutrophils, and multinucleate macrophages (Langhans and foreign body type) admixed with areas of eosinophilic cellular and karyorrhectic debris (necrosis), hemorrhage, fibrin, and edema.  Multifocally, bronchioles contain necrotic cellular exudate.  Diffusely the less affected alveolar septa are expanded up to 5 times normal by macrophages, lymphocytes, plasma cells, fibrin, and edema.  Perivascular and peribronchiolar adventitia, interlobular septa, and pleura are mildly expanded by similar inflammatory cells, ectatic lymphatics (edema), fibrin, and hemorrhage. 

Liver:  Essentially normal tissue.

MORPHOLOGIC DIAGNOSIS:  Lung:  Bronchopneumonia, granulomatous and necrotizing, multifocal to coalescing, moderate, breed unspecified, bovine.

ETIOLOGIC DIAGNOSIS:  Pulmonary brucellosis

CAUSE:  Brucella abortus

CONDITION:  Brucellosis

SYNONYMS:  Bang’s disease

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS

DIFFERENTIAL DIAGNOSIS:

Fetal bronchopneumonia:

COMPARATIVE PATHOLOGY:

References:

  1. Buckls K, Row WD, Howe L, Micheal S, Duignan PJ, Burrows E, Ha H, Humphrey S, McDonald WL. Brucellosis in endangered Hector’s dolphins (Cephalorhynchus hectori).  Vet Pathol. 2017: Jan 1.  doi: 10.1177/0300985817707023. [Epub ahead of print]
  2. Constable PD, Hinchcliff KW, Done SH, Grunberg W. Veterinary Medicine:  A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs, and Goats, Vol 2.  11th ed.  Louis, MO: Elsevier; 2017: 1761-1784.
  3. de Figueiredo P, Ficht TA, Rice-Ficht A, Rossetti CA, Adams LG. Pathogenesis and immunobiology of Brucellosis review of Brucellae-host interactions. Am J. Pathol. 2015;185(6):1505-17.
  4. Dougherty AF, Cornish TE, O’Toole D, Boerger-Fields AM, Henderson OL, Mills KW. Abortion and premature birth in cattle following vaccination with Brucella abortus strain RB51. J Vet Diagn Invest. 2013;25(5):630-635.
  5. Foster, RA. Female reproductive system and mammae.  In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2016: 1174, 1180, 1182, 1183, 1188, 1191.
  6. Foster, RA. Male genital system.  In: Maxie MG, ed. Jubb, Kennedy, and Palmer's Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier; 2016: 473-474, 485-487, 490.
  7. Giambartolomei GH, Scian R, Acosta-Rodriguez E, Fossati CA, Delpino MV. Brucella abortus-infected macrophages modulate T lymphocytes to promote osteoclastogenesis via IL-17. Am J Pathol. 2012;181(3):887-896.
  8. Keestra-Gounder AM, Byndloss MX, Seyffert N, et. al. NOD1 and NOD2 signalling links ER stress with inflammation.  Nature. 2016; 532(7599):394-7.
  9. Lopez A, Martinson SA. Respiratory system, mediastinum, and pleurae. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2016: 552.
  10. Olsen SC, Palmer MV. Advancement of knowledge of Brucella over the past 50 years. Vet Pathol. 2014;51(6):1076-1089.
  11. Reuss, SM. Fistulous withers.  In: Diseases of the bones, joints, and connective tissue.  In: Smith BP, ed.  Large Animal Internal Medicine, 5th ed.  Louis, MO: Elsevier-Mosby; 2015: 1133-1134.
  12. Schlafer DH, Foster RA. Female genital system.  In: Maxie MG, ed. Jubb, Kennedy, and Palmer's Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier; 2016: 402-406.
  13. Tomaselli M, Dalton C, Duignan PJ, Kutz S, et. al. Contagious ecthyma, rangiferine brucellosis, and lungworm infection in a muskox (Ovibos moschatus) from the Canadian arctic, 2014.  Jour Wildlife Disease.  2016;52(3): 719-724.
  14. Troedsson MHT, Christensen BW, eds. Diseases of the reproductive system.  In: Smith BP, ed.  Large Animal Internal Medicine, 5th ed.  Louis, MO: Elsevier-Mosby; 2015: 1347-1348, 1353.
  15. Wilcock BP, Njaa BN. Special senses.  In: Maxie MG, ed. Jubb, Kennedy, and Palmer's Pathology of Domestic Animals. Vol 1. 6th ed. St. Louis, MO: Elsevier; 2016: 449.
  16. Zachary JF. Mechanisms of microbial infections. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2016: 182-184, 192-193.


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