JPC SYSTEMIC PATHOLOGY
SPECIAL SENSES SYSTEM
APRIL 2018
S-M07

SIGNALMENT (JPC Accession # 2237865): A 2-year-old male Akita dog

HISTORY: This dog had a four-month history of progressive periocular and nasal alopecia and depigmentation.

HISTOPATHOLOGIC DESCRIPTION: Eye: Diffusely effacing and replacing the uvea (iris, ciliary body, choroid), the corneal endothelium, and retina, filling the anterior and posterior chambers and vitreous cavity, and multifocally infiltrating the cornea, sclera, and extraocular perivascular connective tissue are numerous macrophages, plasma cells, and lymphocytes admixed with fewer neutrophils. Within all segments, inflammatory cells are mixed with variable amounts of melanin, melanomacrophages, and hemosiderophages, marked hemorrhage and fibrin, eosinophilic and karyorrhectic debris (necrosis), moderate numbers of fibroblasts, and variably sized vessels. There is diffuse moderate corneal epithelial hyperplasia and the corneal stroma is expanded by increased clear space (edema) and moderate numbers of small to medium caliber vessels (vascularization) that are multifocally surrounded by lymphocytes and plasma cells.

MORPHOLOGIC DIAGNOSIS: Eye: Panophthalmitis, granulomatous and lymphoplasmacytic, diffuse, severe, with necrosis, scattered melanin and melanomacrophages (pigment dispersion), hemorrhage, fibrin, and corneal edema, Akita, canine.

ETIOLOGIC DIAGNOSIS: Immune-mediated panophthalmitis

CONDITION: Uveodermatologic syndrome; Vogt-Koyanagi-Harada-like syndrome

GENERAL DISCUSSION: 

PATHOGENESIS: 

TYPICAL CLINICAL/GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

Acquired Hypopigmentation:

Uveitis:

Immune-mediated dermatitis:

COMPARATIVE PATHOLOGY

REFERENCES

  1. Dubielzig RR, Ketring KL, McLellan GJ, Albert DM. Veterinary Ocular Pathology: a comparative review. Louis, MO: Saunders Elsevier; 2010:260-263.
  2. Hargis AM, Myers S. Integumentary system. In: Zachary JF, Pathologic basis of Veterinary Disease. 6th ed. St. Louis, MO: Mosby Inc; 2016:1104. 
  3. Labelle P. The eye. In: Zachary JF, Pathologic basis of Veterinary Disease. 6th ed. St. Louis, MO: Mosby Inc; 2016:1314. 
  4. Wilcock BP, Njaa BL. Special senses. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. 6th ed. Vol 1. St. Louis, MO: Elsevier Inc; 2016:453-454, 456-457.


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