JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
December 2014
U-B09

Signalment (AFIP #1946321):  3-year-old crossbred sow

HISTORY:  An outbreak of disease occurred on a large swine breeding facility.   Symptoms common to a majority of the sick animals were anorexia, high fever, cyanosis and abortion. 

HISTOPATHOLOGIC DESCRIPTION:  Kidney:  Multifocally glomerular tuft and interstitial capillaries contain brightly eosinophilic, hyalinized fibrin thrombi.   Mild edema and fibrin accumulation are present within the tunica adventitia and perivascular tissues of arcuate and intralobular arteries as well as hypertrophy of vascular endothelium.  Multifocally, the interstitium contains a few small aggregates of lymphocytes, plasma cells, macrophages, and occasional neutrophils.  Multifocally tubular epithelial cells exhibit one or more of the following changes: flattening and attenuation; increased cytoplasmic volume and vacuolation (degeneration); shrunken cells with bright eosinophilic cytoplasm, angular margins and dense to pyknotic nuclei (necrosis); sloughing of epithelium into tubular lumina, and accumulation of few erythrocytes and small amounts of flocculant eosinophilic debris.  There are moderate multifocal autolytic changes.

MORPHOLOGIC DIAGNOSIS:  Kidney, glomerular and interstitial capillaries: Fibrin thrombi, acute, multifocal, moderate with lymphoplasmacytic and neutrophilic interstitial nephritis, perivascular edema, and mild tubular degeneration and necrosis, crossbred pig, porcine.

ETIOLOGIC DIAGNOSIS:  Renal erysipelothricosis

CAUSE:  Erysipelothrix rhusiopathiae

CONDITION:  Swine erysipelas; “diamond skin disease”

GENERAL DISCUSSION

PATHOGENESIS

TYPICAL CLINICAL FINDINGS:

Porcine erysipelas occurs in all ages but most susceptible are pregnant sows and pigs 2-12 months old; manifestations vary from acute septicemic (epidemic-associated) and mild, chronic forms (endemic-associated)

posterior thighs and jowls

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Barthold SW, Griffey SM, Percy DH. . Rat. In: Barthold SW, Griffey SM, Percy DH Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, IA: Wiley Blackwell; 2016:141
  2. Breshears MA, Confer AW. The Urinary System. In: Zachary JF ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:675.
  3. Cianciolo RE, Mohr, FC.  Urinary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed.  St Louis, MO: Elsevier; 2016:433.
  4. Craig LE, Dittmer KE, Thompson KG. Bones and joints. In Maxie MG, ed.  Jubb, Kennedy and Palmer’s Pathology of Domestic Animals.  Vol 1. 6th ed.  St Louis, MO: Elsevier; 2016: 149-150
  5. Ersdal C, Jørgensen HJ, and Lie K-I.  Acute and Chronic Erysipelothrix rhusiopathiae Infection in Lambs.  Vet Pathol.  2015; 52(4): 635-643. 
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  8. Karstrup CC, Jensen HE, Aalbaek B, Leifsson PS, et al. Endocarditis-associated brain lesions in slaughter pigs. J Comp Path.  2011;144(4):289-295.
  9. Kinsel MJ, Boehm JR, Harris B, Murnane RD.  Fatal Erysipelothrix rhusiopathiae septicemia in a captive Pacific white-sided dolphin. J Zoo Wildl Med. 1997;28:494-497.
  10. Miller LM, Gal A. Cardiovascular system and lymphatic vessels. In Zachary JF, ed.  Pathologic Basis of Veterinary Disease.  6th ed. St. Louis, MO:  Elsevier; 2017:  608
  11. Robinson WF, Robinson NA. Cardiovascular system. In Maxie MG, ed.  Jubb, Kennedy and Palmer’s Pathology of Domestic Animals.  Vol 3.  6th ed.  St Louis, MO: Elsevier; 2016:  30-31.
  12. Spraker TR, White PA. Shaggy lame fox syndrome in Pribilof island arctic foxes (Alopex lagopus pribilofensis), Alaska. Vet Pathol.  2017: 54(2): 258-268
  13. Zachary JF. Mechanisms of Microbial Infections. In: Zachary JF ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:  191-192.

 


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