JPC SYSTEMIC PATHOLOGY
Musculoskeletal System
April 2019
M-N03 (NP)

Signalment (JPC #2594133):  5-year-old female Chesapeake Bay retriever

HISTORY:  This dog had an 8-month history of progressively worsening lameness of the right rear leg.  Radiographic examination revealed lysis of the right tibial tarsal (tarsus) bone.

HISTOPATHOLOGIC DESCRIPTION:  Bone, tibial tarsal (per contributor):  Filling the marrow cavity, effacing over 75% of normal bone and infiltrating the surrounding connective tissue is an unencapsulated, moderately cellular neoplasm composed of haphazardly arranged plump neoplastic spindle cells surrounded by irregular islands and thick trabeculae of abundant, variably basophilic, chondromatous matrix.  Neoplastic cells are individualized or congregated in lacunae within the matrix and have a moderate amount of finely granular eosinophilic to basophilic cytoplasm.  Nuclei are oval, have 1-2 magenta nucleoli and finely stippled chromatin.  The mitotic count averages less than one per 10 HPF.  Multifocally there are irregular trabeculae of reactive woven bone and foci of osteolysis characterized by scalloped margins and few multinucleated osteoclasts within Howship"s lacunae. Loose, well-vascularized mesenchymal tissue is interspersed between islands of cartilage. There is mild hemorrhage and low numbers of hemosiderophages. 

MORPHOLOGIC DIAGNOSIS:  Bone, tibial tarsal (per contributor):  Chondrosarcoma, Chesapeake Bay retriever, canine.

GENERAL DISCUSSION:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Beck AP, Jones ML. Chondrosarcoma of the scapula of an 8-month-old Holstein steer. J Vet Diagn Invest. 2012;24(4):791-793.
  2. Beckwith-Cohen B, Teixeira LB, Dubielzig RR. Presumed primary intraocular chondrosarcoma in cats. J Vet Diagn Invest. 2014;26(5):664-668).
  3. Farese JP, Kirpensteijn J, Kik M, et al. Biologic behavior and clinical outcome of 25 dogs with canine appendicular chondrosarcoma treated by amputation: A veterinary society of surgical oncology retrospective study. Vet Surg. 2009;38:914-919.
  4. Olson EJ, Carlson CS. Bones, joints, tendons, and ligaments. In: McGavin MD, Zachary JF, eds. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier Inc; 2017; 992.
  5. Ramirez GA, Altimira J, Vilafranca M. Cartilagenous tumors of the larynx and trachea in the dog: Literature review and 10 additional cases (1995-2014).  Vet Pathol.  2015;52(6):1019-26.
  6. Thompson K. Bones and joints. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA: Saunders Elsevier; 2016: 118-120.
  7. Thompson KG, Dittmer KE. Tumors of Bone. In: Meuten, DJ, ed. Tumors in Domestic Animals. 5th ed. Ames, IA; John Wiley & Sons, Inc; 2017: 394-400.


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