JPC SYSTEMIC PATHOLOGY

INTEGUMENTARY SYSTEM

October 2016

I-N30 (NP)

 

Signalment (JPC #2681629):  Adult boa constrictor (Boa constrictor constrictor)

HISTORY:  A 1 cm diameter skin mass that recurred after surgical excision

HISTOPATHOLOGIC DESCRIPTION:  Skin:  Expanding the dermis and elevating the multifocally ulcerated epidermis is a 2 x 1.5 cm unencapsulated, multilobulated, infiltrative, pigmented neoplasm.  Neoplastic cells are polygonal to spindle and arranged in nests and packets on a fine fibrovascular stroma; neoplastic cells frequently spindle forming interlacing bundles, short streams and whorls.  Cells have indistinct borders, a moderate amount of eosinophilic granular cytoplasm with variable amounts of gold-brown to green granular, birefringent pigment, an oval to elongate nucleus with coarsely clumped chromatin and variably distinct nucleoli.  Mitoses average 3 per HPF.  Rarely, small nests of neoplastic cells extend into the epidermis (junctional activity).  Vessels within the neoplasm are surrounded by variable numbers of lymphocytes, plasma cells, histiocytes and granulocytes.  There is a focally extensive area of ulceration with granulation tissue in the underlying dermis and epidermal hyperplasia with hyperkeratosis in the adjacent epidermis. 

MORPHOLOGIC DIAGNOSIS:  Skin:  Iridophoroma, malignant, Boa constrictor (Boa constrictor constrictor), reptile.

GENERAL DISCUSSION:

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Catao-Dias JL, Nichols DK. Neoplasia in snakes at the National Zoological Park, Washington DC (1978-1997). J Comp Path. 1999;120:89-95.
  2. Cheville NF. Ultrastructural Pathology: An Introduction to Interpretation. 2nd Ames, IA: Iowa State University Press;2009:815.
  3. De Brot S, Sydler T, Nufer L, Ruetten M. Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona Henrylawsoni). J Zoo Wildl Med. 2013; 46(3):583-587.
  4. Frye FL. Reptile Care: An Atlas of Diseases and Treatments. Vol 1. Neptune City, NJ:THF Publications, Inc;1991:473-511.
  5. Gregory CR, Harmon BG, Lattimer KS, Campagnoli RP, McManamon RM, Steffens WL. Malignant chromatophoroma in a canebrake rattlesnake (Crotalus horridus atricaudatus). J Zoo Wildl Med. 1997;28(2):198-203.
  6. Heckers KO, Aupperle H, Schmidt V, Pees M. Melanophoromas and iridophoromas in reptiles. J Comp Path. 2012;146:258-268.
  7. Munoz-Gutierrez JF, Garner MM, Kiupel M. Cutaneous chromatophoromas in captive snakes. Vet Pathol. 2016; 53(6):1213-1219.
  8. Okihiro MS: Chromatophoromas in two species of Hawaiian butterfly fish, Chaetodon multicinctus and miliaris. Vet Pathol. 1988;25:422-431.


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