JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
December 2017
U-M01

Signalment:  4-year-old woolly monkey, gender unspecified

HISTORY:  Unknown

HISTOPATHOLOGIC DESCRIPTION: Kidney: Approximately 70% of arteries and arterioles are tortuous and frequently the intima are circumferentially and moderately thickened by the deposition of eosinophilic, fibrillar material (collagen, elastic fibers), which narrows and occasionally occludes vessel lumina. The tunica media of these vessels is moderately thickened by concentric layers of loosely arranged leiomyocytes (smooth muscle hyperplasia and "onion skinning"). Leiomyocytes occasionally have vacuolated sarcoplasm and hyperchromatic nuclei (degeneration). Frequently, the tunica adventitia of these vessels is mildly expanded by fibrosis. Multifocally, infiltrating the cortical interstitium and often linearly tracking vessels, there are numerous lymphocytes and plasma cells mixed with loosely arranged fibrous connective tissue (fibrosis), minimal hemorrhage and few hemosiderin-laden macrophages, which surround, separate and replace tubules and glomeruli. Among the remaining tubules, there is often tubular atrophy and loss, or tubules are ectatic and lined by attenuated epithelium. Tubules occasionally contain eosinophilic, homogenous, flocculent or granular material (granular casts and tubular proteinosis). Multifocally, Bowman’s capsule is mildly thickened by fibrous connective tissue and occasionally there is segmental or global glomerulosclerosis and atrophy of glomerular tufts. Within the medulla, there is marked interstitial fibrosis with similar tubular changes. Multifocally, the overlying capsule is undulant with multifocal indentations in areas with subjacent inflammation,  and fibrosis.

MORPHOLOGIC DIAGNOSES:

  1. Kidney, arteries and arterioles: Arteriosclerosis, hyperplastic, circumferential, multifocal, moderate, woolly monkey, (Lagothrix lagothrica), primate.
  2. Kidney: Nephritis, tubulointerstitial, lymphoplasmacytic, chronic, diffuse, moderate with fibrosis, glomerulosclerosis and tubular proteinosis.

ETIOLOGIC DIAGNOSIS: Idiopathic hypertensive renal arteriosclerosis

CAUSE: Essential (Idiopathic) hypertension

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSES:

COMPARATIVE PATHOLOGY:

References:

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  2. Cline MJ, Bringolo L, Ford EW. Urogenital system. In: In: Abee CR, Mansfield K, Tardiff S, Morris T, eds. Nonhuman Primates in Biomedical Research: Diseases. 2nd ed. Vol. 2. San Diego, CA: Academic Press; 2012:494.
  3. Giddens WE, Combs CA, Smith OA, Klein EC. Spontaneous hypertension and its sequelae in woolly monkeys (Lagothrix lagotricha). Lab Anim Sci. 1987; 37:750-756.
  4. Kohnken R, Scansen BA, et al. Vasa vasorum arteriopathy: Relationship with systemic arterial hypertension and other vascular lesions in cats. Vet Pathol. 2017; 54(3):475-483.
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  6. Miller LM, Gal A. Cardiovascular system and lymphatic vessels. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. ed. 6th ed. Mosby, St. Louis, MO; 2017:600.
  7. Owens DR. Spontaneous, surgically and chemically induced models of disease. In: Suckow MA, Weisbroth SH, Franklin CL, eds. The Laboratory Rat. 2nd ed. Academic Press, San Diego; 2006:717-719.
  8. Porter BF, Frost P, Hubbard GB: Polyarteritis in a cynomolgus macaque (Macaca fascicularis). Vet Pathol. 2003; 40:570-573.
  9. Roberts JA, Ford EW, Southers JL: Part A Urinary System. In: Bennett BT, Abee CR, Henrickson R, eds. Non-Human Primates in Biomedical Research: Diseases. Academic Press, San Diego; 1998:318-319.
  10. Robinson W, Robinson N. Cardiovascular system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. Philadelphia, PA:Elsevier; 2016:71.
  11. Wagner JD, Cann JA, Zhang L, Harwood JH. Diabetes and obesity research using nonhuman primates. . In: Abee CR, Mansfield K, Tardiff S, Morris T, eds. Nonhuman Primates in Biomedical Research: Diseases. 2nd ed. Vol. 2. San Diego, CA: Academic Press; 2012:716-717.

 

 


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