JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
September 2018
D-N04

Signalment (JPC #1800099): Adult cat

HISTORY: None

HISTOPATHOLOGIC DESCRIPTION:  Slide A:  Small intestine:  Focally and markedly expanding the tunica muscularis, submucosa, and lamina propria, is an 8 x 4 mm, unencapsulated, well-demarcated, infiltrative neoplasm composed of round cells arranged in sheets and vague cords.  Neoplastic cells have variably distinct cell borders, a moderate amount of pale, eosinophilic, finely granular cytoplasm, a round to oval, centrally located nucleus with finely-stippled chromatin and one variably distinct nucleolus.  Anisocytosis and anisokarryosis are mild, and mitotic figures average 1 per 10 HPF.  Neoplastic cells are admixed with low numbers of eosinophils and rare lymphocytes and plasma cells.  Within the tunica muscularis, neoplastic mast cells surround and separate myocytes.  Neoplastic mast cells expand the lamina propria, surrounding and separating crypts that are often elongated, or hyperplastic, lined by cells with enlarged vesiculate nuclei that are often piling up, and contain mitotic figures within the more superficial mucosa.  There is a focally extensive area of hemorrhage within the inner circular layer of the tunica muscularis adjacent to neoplastic cells. 

Slide B (Giemsa):  Multifocally, neoplastic cells contain metachromatic cytoplasmic granules

MORPHOLOGIC DIAGNOSIS:  Small intestine:  Mast cell tumor, breed not specified, feline

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSES:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Brosinski K,Burkhardt WA, Venzin C, Grest P. Diagnostic exercise: Submucosal gastric masses in a cat.Vet Pathol. 2013;50(2):350-353.
  2. Craig LE, Hardam EE, Hertzke DM, Flatland B, Rohrbach BW, Moore RR. Feline gastrointestinal eosinophilic sclerosing fibroplasias. Vet Pathol. 2009; 46:63-70.
  3. Gelberg, HB. Alimentary system and the peritoneum, omentum, mesentery, and peritoneal cavity. In: McGavin MD, Zachary JF, eds. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:330.
  4. Hillman LA, et al. Biological behavior of oral and perioral mast cell tumors in dogs: 44 cases (1996-2006). J Am Vet Med Assoc. 2010; 237(8):936-942.
  5. Hyland JE, Sartin EA, Spangler EA. Pathology in Practice. J Am Vet Med Assoc. 2013;242(5): 627-629.
  6. Mallett CL, et al. Immunohistochemical characterization of feline mast cell tumors. Vet Pathol. 2012;50(1):106.
  7. Meuten DJ. Tumors in Domestic Animals, 5th ed. Ames, IA: John Wiley & Sons, Inc.; 2017:195-202, 547, 577-579, 585-587.
  8. Rodriguez-Cariño C, Fondevila D, Segalés J, Rabanal RM. Expression of KIT receptor in feline cutaneous mast cell tumors. Vet Pathol. 2009;46:878-883.
  9. Smith AJ, Njaa BL, Lamm CG. Immunohistochemical expression of c-KIT protein in feline soft tissue fibrosarcomas. Vet Pathol. 2009;46:934-939.
  10. Uzal FA, Plattner BL, Hostetter JM. Alimentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier; 2016:27, 109.
  11. Vogel P, Janke, L, Gravano DM, et al. Globule leukocytes and other mast cells in the mouse intestine. Vet Pathol. 2018; 55(1): 76-97.


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