JPC SYSTEMIC PATHOLOGY

INTEGUMENTARY SYSTEM

September 2016

I-M01 (NP)

Signalment:  Rhesus monkey (Macaca mulatta)

HISTORY:  Tissue from the eyelid 48 hours after an intradermal injection of tuberculin.

HISTOPATHOLOGIC DESCRIPTION:  Haired skin, eyelid (per contributor):  The superficial and deep dermis is expanded by perivascular accumulations of large numbers of lymphocytes, fewer plasma cells, and macrophages.  Multifocally, a similar infiltrate separates and isolates collagen bundles, muscle fibers, and adnexa.  Associated blood vessels often contain numerous transmigrating inflammatory cells and are occasionally lined by reactive endothelial cells.  Multifocally the connective tissue is loosely arranged and expanded by clear space (edema) and fibrin.  The epidermis is mildly hyperplastic with parakeratosis and a serocellular crust composed of eosinophilic material (serum), degenerate neutrophils, fibrin, and erythrocytes.

MORPHOLOGIC DIAGNOSIS:  Haired skin, eyelid (per contributor):  Dermatitis, lymphohistiocytic, perivascular, multifocal, moderate, with hemorrhage and edema, rhesus monkey (Macaca mulatta), non­human primate.

CONDITION:  Positive tuberculin test (type IV/delayed-type hypersensitivity)

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

COMPARATIVE PATHOLOGY:

 REFERENCES:

  1. Kumar V, Abbas AK, Aster JC. Diseases of the immune system. In: Kumar V, Abbas AK, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2015:210-212.
  2. McAdam AJ, Milner DA, Sharpe AH. Infectious diseases. In: Kumar V, Abbas AK, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2015:371-378.
  3. Snyder, PW. Diseases of immunity. In: Zachary JF, McGavin MD, eds. Pathologic Basis of Veterinary Disease. 5th ed. St. Louis, MO: Elsevier Mosby; 2012:266-270.
  4. Abee RA, Mansfield K, Morris T, Tardif S, eds. Nonhuman Primates in Biomedical Research: Biology and Management. 2nd Waltham, M: Elsevier: 2012:308-310.


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