JPC SYSTEMIC PATHOLOGY
CARDIOVASCULAR SYSTEM
April 2019
CM03

Signalment (JPC #1713374):  9-week-old female Siamese cat

HISTORY:  This cat presented with severe dyspnea.

HISTOPATHOLOGIC DESCRIPTION:  Heart:  Diffusely the endocardium is uniformly thickened up to 250 um (20x normal) by numerous fibrocytes, fewer fibroblasts, and many layers of collagen and elastic fibers. Superficially, fibers are thin, loosely and randomly arranged, and separated by increased clear space and myxomatous material. Fibers within the deeper layers are thicker, more tightly packed, and are parallel. Multifocally the connective tissue extends minimally into the underlying myocardium, rarely surrounding and isolating myofibers and Purkinje fibers.

MORPHOLOGIC DIAGNOSIS:  Heart, endocardium:  Fibroelastosis, diffuse, marked, Siamese, feline.

CONDITION:  Endocardial fibroelastosis (EFE)

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Cushing TL. Endocardial fibroelastosis in a quarterhorse mare. J Comp Pathol. 2013;149(2-3):318-321.
  2. Donovan TA, Balakrishnan N, et al. Bartonella as a possible cause or cofactor of feline endomyocarditis-left ventricular endocardial fibrosis complex. J Comp Path. 2018;162:29-42.
  3. Kimura Y, Karakama S, et al. Pathological features and pathogenesis of the endomyocardial form of restrictive cardiomyopathy in cats. J Comp Pathol. 2016;155(2-3):190-198.
  4. McEndaffer L, Molesan A, Erb H, Kelly K. Feline panleukopenia virus is not associated with myocarditis or endomyocardial restrictive cardiomyopathy in cats. Vet Pathol. 2017;54(4):669-675.
  5. Miller LM, Gal A. Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:595.
  6. Robinson WF, Robinson NA. Cardiovascular system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier; 2016:22, 30.
  7. Schoen FJ, Mitchell RN. The heart. In: Kumar V, Abbas AK, Fausto N, Aster J, eds. Robbins and Cotran Pathologic Basis of Disease. 9th ed. St. Louis, MO: Elsevier; 2015:570.
  8. Gudenschwager EK, Abbott JA, LeRoith T. Dilated cardiomyopathy with endocardial fibroelastosis in a juvenile Pallas cat. J Vet Diagn Invest. 2019; 31(2):289-293.


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