JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
October 2018
D-P22

Signalment (JPC# 2317378):  Laboratory mouse

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Liver:  Focally expanding, compressing, and replacing hepatic parenchyma is a 4 mm diameter, thin-walled, parasitic cyst that contains multiple sections of a larval cestode (strobilocercus).  The cestode is 2 mm in diameter with a segmented strobila that lacks a pseudocoelom and digestive tract, has a 10-20 um thick homogenous acellular external layer supported by a basement membrane (tegument),  longitudinal subtegumental and transverse parenchymal muscle layers, and numerous 10 x 5 um diameter, oval, clear structures containing central basophilic to eosinophilic amorphous material (calcareous corpuscles).  Surrounding the cyst is a thick, up to 100 um wide, fibrous capsule that is multifocally infiltrated by plasma cells, lymphocytes, neutrophils, few macrophages and rare eosinophils.  Scattered throughout the remaining parenchyma, there are aggregates of myeloid and erythroid precursors (extramedullary hematopoiesis). 

MORPHOLOGIC DIAGNOSIS:  Liver:  Strobilocercus, focally extensive, etiology consistent with Cysticercus fasciolaris, breed unspecified, murine.

ETIOLOGIC DIAGNOSIS: Hepatic cysticercosis/strobilocercosis

CAUSE:  Cysticercus fasciolaris

GENERAL DISCUSSION:

PATHOGENESIS:

LIFE CYCLE:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

ADULT TAPEWORM

DEFINITIVE HOST

LARVAL FORM

INTERMEDIATE HOST

SITE - IH

Taenia saginata

man

Cysticercus bovis

cattle

muscle

Taenia solium

man

Cysticercus cellulosae

pig, man

muscle

Taenia(Multiceps) multiceps

dog

Coenurus cerebralis

sheep, cattle

CNS

Taenia hydatigena

dog

Cysticercus tenuicollis

sheep, cattle, pig

peritoneum

Taenia ovis

dog

Cysticercus ovis

sheep

muscle

Taenia pisiformis

dog

Cysticercus pisiformis

rabbit

peritoneum

Taenia serialis

dog

Coenurus serialis

rabbit

connective tissue

Taenia taeniaeformis

cat

Cysticercus fasciolaris (strobilocercus)

mouse, rat, hamster

liver

Taenia krabbei

dog

Cysticercus tarandi

reindeer

muscle

Taenia mustelae

wild felids

 

rodents

liver

Diphyllobothrium latum

bear, man

sparganum

fish

muscle

Diphyllobothrium pacificum

seal, sea lion

sparganum

marine birds

muscle

Spirometra sp

dogs, cats, lynx, racoons

Plerocercoid

“sparganum”

tadpoles, snakes, rodents

connective tissue

REFERENCES:

  1. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, IA: John Wiley & Sons; 2016: 85,153,190,302.
  2. Bowman DD. Georgi's Parasitology for Veterinarians. 10th ed. St. Louis, MO: Elsevier Saunders; 2014:137-148,412-417.
  3. Brown DL, Van Wettere AJV, Cullen JM. Hepatobiliary system and exocrine pancreas. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:446.
  4. Gardiner CH, Poynton SL. An Atlas of Metazoan Parasites in Animal Tissues. Washington, DC: American Registry of Pathology; 1998:50-55.
  5. Lee BW, Jeon BK, Kim HS, Yoon BI. Cysticercus fasciolaris infection in wild rats (Rattus norvegicus) in Korea and formation of cysts by remodeling of collagen fibers. J Vet Diagn Invest. 2016:28(3):263-270.
  6. Strait K, Else JG, Eberhard ML. Parasitic diseases of Nonhuman primates. In: Abee CR, Mansfield K, Tardif S, Morris T, eds. Nonhuman Primates in Biomedical Research: Diseases. 2nd San Diego, CA: Academic Press; 2012: 254-257.
  7. Uzal FA, Plattner BL, Hostetter JM. Alimentary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier; 2016:223-225.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |