JPC SYSTEMIC PATHOLOGY
Musculoskeletal System
March 2019
M-M17

Signalment (JPC #2984970):  Great Dane

HISTORY:  This 15-week-old female puppy presented with a 3-day history of generalized pain, reluctance to walk followed by lateral recumbency.

HISTOPATHOLOGIC DESCRIPTION:  Long bone:  Diffusely the metaphyseal primary spongiosa are characterized by elongated mineralized spicules of cartilage devoid of osteoid and lined by decreased numbers of osteoblasts.  Diffusely within the metaphysis, these calcified cartilage spicules extend well into the metaphysis and are frequently discontinuous and fragmented with sharp angular borders (microfractures) coalescing to form a large infraction with separation of the proximal and distal metaphysis.  Separating the calcified spicules of the primary spongiosa and bony trabeculae of the secondary spongiosa are abundant mature neutrophils, reactive fibroblasts (fibrosis), fibrin, hemorrhage and necrotic debris.  Multifocally, scattered vessels throughout the epiphysis, metaphysis, and periosteum contain fibrin thrombi with expansion of vessel wall by small amounts of necrotic debris and fibrin (vascular necrosis).

MORPHOLOGIC DIAGNOSIS:  Long bone: Osteomyelitis, necrosuppurative, acute, diffuse, severe, with microfractures, infraction, and fibrin thrombi, Great Dane, canine.

CONDITION:  Metaphyseal osteopathy

SYNONYMS:  Hypertrophic osteodystrophy (HOD); osteodystrophy II; skeletal scurvy; juvenile scurvy; Moller-Barlow's disease

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Craig LE, Dittmer KE, Thompson K. Bones and joints. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. St. Louis, MO: Elsevier Saunders; 2016:105-106.
  2. Olson EJ, Carlson CS. Bones, joints, tendons, and ligaments. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:1006-1007.


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