JPC SYSTEMIC PATHOLOGY
HEMOLYMPHATIC SYSTEM
April 2018
H-B11 (NP)

Signalment (AFIP # POLA 27):  German shepherd dog, age and gender not specified

HISTORY:  A blood smear was obtained from an emaciated German shepherd dog.

HISTOPATHOLOGIC DESCRIPTION:  Peripheral blood smear:  The sample is of low cellularity.  Rarely, monocytes contain round to oval, 4-6 um diameter, basophilic intracytoplasmic rickettsial morulae. 

MORPHOLOGIC DIAGNOSIS:  Cytologic specimen, peripheral blood smear:  Intramonocytic ehrlichial morulae, few, German shepherd dog, canine.

CAUSE:  Ehrlichia canis

CONDITION:  Canine monocytotropic ehrlichiosis (CME)

SYNONYMS:  Canine tropical pancytopenia, tracker dog disease, canine hemorrhagic fever

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

CLINICAL PATHOLOGY:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

Ehrlichia canis

Rickettsia rickettsii

Incidence all year

Tick season (April-September)

All ages of dogs

Young dogs  (< 2yrs)

Purebreds susceptible; esp. German shepherds

Purebreds susceptible

Chronic and progressive

Rapid and severe

Anemia, leukopenia, thrombocytopenia

Leukocytosis and thrombocytopenia

Hyperglobulinemia and hypoalbuminemia

Hypoalbuminemia, high serum alk phos & cholesterol

Lymphoplasmacytic cuffing

Necrotizing vasculitis

Serology; PCR

Tissue IFA; PCR

COMPARATIVE PATHOLOGY:

Other rickettsial bacteria that infect leukocytes:

Rickettsial bacteria that infect erythrocytes:

`REFERENCES

  1. Boes KM, Durham AC. Bone marrow, blood cells, and the lymphoid/lymphatic system. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:749-50.
  2. Sykes JE. Ehrlichiosis, anaplasmosis, Rocky Mountain spotted fever, and neorickettsiosis. In: Ettinger SJ, Feldman EC, Cote E, eds Textbook of Veterinary Internal Medicine. 8th ed. St Louis, MO:Elsevier Saunders; 2017:944-951.
  3. Harrus S, Waner T, Neer TM. Ehrlichia canis In: Greene CE, ed. Infectious Diseases of the Dog and Cat. 4th ed. St. Louis, MO: Saunders; 2012:227-238.
  4. Valli VEO, Kiupel M, Bienzle D. Hematopoietic system: In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:111.

 

 


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